IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-25456-z.html
   My bibliography  Save this article

BMP8 and activated brown adipose tissue in human newborns

Author

Listed:
  • Adela Urisarri

    (University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana)

  • Ismael González-García

    (University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn))

  • Ánxela Estévez-Salguero

    (University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn))

  • María P. Pata

    (Biostatech Advice, Training and Innovation in Biostatistics)

  • Edward Milbank

    (University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn))

  • Noemi López

    (University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana)

  • Natalia Mandiá

    (University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana)

  • Carmen Grijota-Martinez

    (Faculty of Biology, Complutense University)

  • Carlos A. Salgado

    (University of Santiago de Compostela)

  • Rubén Nogueiras

    (University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn))

  • Carlos Diéguez

    (University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn))

  • Francesc Villarroya

    (CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)
    Universitat de Barcelona (IBUB), and Institut de Recerca Hospital Sant Joan de Déu)

  • José-Manuel Fernández-Real

    (CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)
    Faculty of Medicine, University of Girona
    Endocrinology and Nutrition (UDEN), Hospital of Girona Dr. Josep Trueta)

  • María L. Couce

    (University Clinical Hospital of Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), CIBER Enfermedades Raras (CIBERER), Travesia Choupana)

  • Miguel López

    (University of Santiago de Compostela–Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
    CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn))

Abstract

The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been mainly due to the lack of appropriate investigation methods, ethically suitable for neonates. Here, we have applied non-invasive infrared thermography (IRT) to investigate neonatal BAT activity. Our data show that BAT temperature correlates with body temperature and that mild cold stimulus promotes BAT activation in newborns. Notably, a single short-term cold stimulus during the first day of life improves the body temperature adaption to a subsequent cold event. Finally, we identify that bone morphogenic protein 8B (BMP8B) is associated with the BAT thermogenic response in neonates. Overall, our data uncover key features of the setup of BAT thermogenesis in newborns.

Suggested Citation

  • Adela Urisarri & Ismael González-García & Ánxela Estévez-Salguero & María P. Pata & Edward Milbank & Noemi López & Natalia Mandiá & Carmen Grijota-Martinez & Carlos A. Salgado & Rubén Nogueiras & Carl, 2021. "BMP8 and activated brown adipose tissue in human newborns," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25456-z
    DOI: 10.1038/s41467-021-25456-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-25456-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-25456-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Rebecca Oelkrug & Lisbeth Harder & Mehdi Pedaran & Anne Hoffmann & Beke Kolms & Julica Inderhees & Sogol Gachkar & Julia Resch & Kornelia Johann & Olaf Jöhren & Kerstin Krause & Jens Mittag, 2023. "Maternal thyroid hormone receptor β activation in mice sparks brown fat thermogenesis in the offspring," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Antía González-Vila & María Luengo-Mateos & María Silveira-Loureiro & Pablo Garrido-Gil & Nataliia Ohinska & Marco González-Domínguez & Jose Luis Labandeira-García & Cristina García-Cáceres & Miguel L, 2023. "Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25456-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.