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Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates

Author

Listed:
  • Cayla A. Wood

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences)

  • Sangheon Han

    (The University of Texas MD Anderson Cancer Center
    Rice University)

  • Chang Soo Kim

    (The University of Texas MD Anderson Cancer Center)

  • Yunfei Wen

    (The University of Texas MD Anderson Cancer Center)

  • Diego R. T. Sampaio

    (The University of Texas MD Anderson Cancer Center
    University of São Paulo)

  • Justin T. Harris

    (NanoHybrids, Inc.)

  • Kimberly A. Homan

    (NanoHybrids, Inc.)

  • Jody L. Swain

    (The University of Texas MD Anderson Cancer Center)

  • Stanislav Y. Emelianov

    (School of Electrical and Computer Engineering, Georgia Institute of Technology
    Georgia Institute of Technology and Emory University School of Medicine)

  • Anil K. Sood

    (The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
    The University of Texas MD Anderson Cancer Center)

  • Jason R. Cook

    (NanoHybrids, Inc.)

  • Konstantin V. Sokolov

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
    Rice University
    The University of Texas at Austin)

  • Richard R. Bouchard

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences)

Abstract

Photoacoustic (PA) imaging is a functional and molecular imaging technique capable of high sensitivity and spatiotemporal resolution at depth. Widespread use of PA imaging, however, is limited by currently available contrast agents, which either lack PA-signal-generation ability for deep imaging or their absorbance spectra overlap with hemoglobin, reducing sensitivity. Here we report on a PA contrast agent based on targeted liposomes loaded with J-aggregated indocyanine green (ICG) dye (i.e., PAtrace) that we synthesized, bioconjugated, and characterized to addresses these limitations. We then validated PAtrace in phantom, in vitro, and in vivo PA imaging environments for both spectral unmixing accuracy and targeting efficacy in a folate receptor alpha-positive ovarian cancer model. These study results show that PAtrace concurrently provides significantly improved contrast-agent quantification/sensitivity and SO2 estimation accuracy compared to monomeric ICG. PAtrace’s performance attributes and composition of FDA-approved components make it a promising agent for future clinical molecular PA imaging.

Suggested Citation

  • Cayla A. Wood & Sangheon Han & Chang Soo Kim & Yunfei Wen & Diego R. T. Sampaio & Justin T. Harris & Kimberly A. Homan & Jody L. Swain & Stanislav Y. Emelianov & Anil K. Sood & Jason R. Cook & Konstan, 2021. "Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25452-3
    DOI: 10.1038/s41467-021-25452-3
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    Cited by:

    1. Jianwen Song & Xiaoying Kang & Lu Wang & Dan Ding & Deling Kong & Wen Li & Ji Qi, 2023. "Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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