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Programming ultrasensitive threshold response through chemomechanical instability

Author

Listed:
  • Young-Joo Kim

    (Seoul National University)

  • Junho Park

    (Seoul National University)

  • Jae Young Lee

    (Seoul National University)

  • Do-Nyun Kim

    (Seoul National University
    Seoul National University
    Seoul National University)

Abstract

The ultrasensitive threshold response is ubiquitous in biochemical systems. In contrast, achieving ultrasensitivity in synthetic molecular structures in a controllable way is challenging. Here, we propose a chemomechanical approach inspired by Michell’s instability to realize it. A sudden reconfiguration of topologically constrained rings results when the torsional stress inside reaches a critical value. We use DNA origami to construct molecular rings and then DNA intercalators to induce torsional stress. Michell’s instability is achieved successfully when the critical concentration of intercalators is applied. Both the critical point and sensitivity of this ultrasensitive threshold reconfiguration can be controlled by rationally designing the cross-sectional shape and mechanical properties of DNA rings.

Suggested Citation

  • Young-Joo Kim & Junho Park & Jae Young Lee & Do-Nyun Kim, 2021. "Programming ultrasensitive threshold response through chemomechanical instability," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25406-9
    DOI: 10.1038/s41467-021-25406-9
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    Cited by:

    1. Jae Young Lee & Yanggyun Kim & Do-Nyun Kim, 2024. "Predicting the effect of binding molecules on the shape and mechanical properties of structured DNA assemblies," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Jae Young Lee & Heeyuen Koh & Do-Nyun Kim, 2023. "A computational model for structural dynamics and reconfiguration of DNA assemblies," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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