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Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

Author

Listed:
  • Weixian Xi

    (University of California Los Angeles
    David Geffen School of Medicine at University of California Los Angeles)

  • Vishal Hegde

    (David Geffen School of Medicine at University of California Los Angeles)

  • Stephen D. Zoller

    (David Geffen School of Medicine at University of California Los Angeles)

  • Howard Y. Park

    (David Geffen School of Medicine at University of California Los Angeles)

  • Christopher M. Hart

    (David Geffen School of Medicine at University of California Los Angeles)

  • Takeru Kondo

    (University of California Los Angeles School of Dentistry)

  • Christopher D. Hamad

    (David Geffen School of Medicine at University of California Los Angeles)

  • Yan Hu

    (David Geffen School of Medicine at University of California Los Angeles)

  • Amanda H. Loftin

    (David Geffen School of Medicine at University of California Los Angeles)

  • Daniel O. Johansen

    (David Geffen School of Medicine at University of California Los Angeles)

  • Zachary Burke

    (David Geffen School of Medicine at University of California Los Angeles)

  • Samuel Clarkson

    (David Geffen School of Medicine at University of California Los Angeles)

  • Chad Ishmael

    (David Geffen School of Medicine at University of California Los Angeles)

  • Kellyn Hori

    (David Geffen School of Medicine at University of California Los Angeles)

  • Zeinab Mamouei

    (David Geffen School of Medicine at University of California Los Angeles)

  • Hiroko Okawa

    (University of California Los Angeles School of Dentistry)

  • Ichiro Nishimura

    (University of California Los Angeles School of Dentistry)

  • Nicholas M. Bernthal

    (David Geffen School of Medicine at University of California Los Angeles)

  • Tatiana Segura

    (University of California Los Angeles
    Duke University)

Abstract

Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Our coating technology uses an in situ coupling reaction of branched poly(ethylene glycol) and poly(allyl mercaptan) (PEG-PAM) polymers to generate an amphiphilic polymeric coating. We show in vivo efficacy in preventing implant infection in both post-arthroplasty infection and post-spinal surgery infection mouse models. Our technology displays efficacy with or without systemic antibiotics, the standard of care. Our coating technology is applied in a clinically relevant time frame, does not require modification of implant manufacturing process, and does not change the implant shelf life.

Suggested Citation

  • Weixian Xi & Vishal Hegde & Stephen D. Zoller & Howard Y. Park & Christopher M. Hart & Takeru Kondo & Christopher D. Hamad & Yan Hu & Amanda H. Loftin & Daniel O. Johansen & Zachary Burke & Samuel Cla, 2021. "Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25383-z
    DOI: 10.1038/s41467-021-25383-z
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