IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-25331-x.html
   My bibliography  Save this article

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

Author

Listed:
  • Yanyun Du

    (Huazhong University of Science and Technology)

  • Rui Shi

    (Chinese Academy of Sciences)

  • Ying Zhang

    (Peking University)

  • Xiaomin Duan

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Li Li

    (Shanghai Junshi Biosciences Co., Ltd)

  • Jing Zhang

    (Shanghai Junshi Biosciences Co., Ltd)

  • Fengze Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Ruixue Zhang

    (Peking University)

  • Hao Shen

    (Peking University)

  • Yue Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zheng Wu

    (Chinese Academy of Sciences
    Anhui University)

  • Qianwen Peng

    (Huazhong University of Science and Technology)

  • Ting Pan

    (Huazhong University of Science and Technology)

  • Wanwei Sun

    (Huazhong University of Science and Technology)

  • Weijin Huang

    (National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals)

  • Yue Feng

    (Beijing University of Chemical Technology)

  • Hui Feng

    (Shanghai Junshi Biosciences Co., Ltd)

  • Junyu Xiao

    (Peking University)

  • Wenjie Tan

    (Chinese Center for Disease Control and Prevention)

  • Youchun Wang

    (National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals)

  • Chenhui Wang

    (Huazhong University of Science and Technology)

  • Jinghua Yan

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

The successive emergences and accelerating spread of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages and evolved resistance to some ongoing clinical therapeutics increase the risks associated with the coronavirus disease 2019 (COVID-19) pandemic. An urgent intervention for broadly effective therapies to limit the morbidity and mortality of COVID-19 and future transmission events from SARS-related coronaviruses (SARSr-CoVs) is needed. Here, we isolate and humanize an angiotensin-converting enzyme-2 (ACE2)-blocking monoclonal antibody (MAb), named h11B11, which exhibits potent inhibitory activity against SARS-CoV and circulating global SARS-CoV-2 lineages. When administered therapeutically or prophylactically in the hACE2 mouse model, h11B11 alleviates and prevents SARS-CoV-2 replication and virus-induced pathological syndromes. No significant changes in blood pressure and hematology chemistry toxicology were observed after injections of multiple high dosages of h11B11 in cynomolgus monkeys. Analysis of the structures of the h11B11/ACE2 and receptor-binding domain (RBD)/ACE2 complexes shows hindrance and epitope competition of the MAb and RBD for the receptor. Together, these results suggest h11B11 as a potential therapeutic countermeasure against SARS-CoV, SARS-CoV-2, and escape variants.

Suggested Citation

  • Yanyun Du & Rui Shi & Ying Zhang & Xiaomin Duan & Li Li & Jing Zhang & Fengze Wang & Ruixue Zhang & Hao Shen & Yue Wang & Zheng Wu & Qianwen Peng & Ting Pan & Wanwei Sun & Weijin Huang & Yue Feng & Hu, 2021. "A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25331-x
    DOI: 10.1038/s41467-021-25331-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-25331-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-25331-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zhenzhen Wang & Shiqi Hu & Kristen D. Popowski & Shuo Liu & Dashuai Zhu & Xuan Mei & Junlang Li & Yilan Hu & Phuong-Uyen C. Dinh & Xiaojie Wang & Ke Cheng, 2024. "Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25331-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.