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Engineered whole cut meat-like tissue by the assembly of cell fibers using tendon-gel integrated bioprinting

Author

Listed:
  • Dong-Hee Kang

    (Osaka University)

  • Fiona Louis

    (Joint Research Laboratory (TOPPAN INC.) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University)

  • Hao Liu

    (Osaka University)

  • Hiroshi Shimoda

    (Hirosaki University Graduate School of Medicine)

  • Yasutaka Nishiyama

    (NH Foods, Ltd.)

  • Hajime Nozawa

    (Kirin Central Research Institute, Kirin Holdings Company, Ltd.)

  • Makoto Kakitani

    (Kirin Central Research Institute, Kirin Holdings Company, Ltd.)

  • Daisuke Takagi

    (Biomedical Business Center, Healthcare Business Group, Ricoh Company, Ltd.)

  • Daijiro Kasa

    (Solution Planning, Product Solution Technologies, Production Printing, Industrial Solutions, Ricoh Japan Corporation)

  • Eiji Nagamori

    (Osaka Institute of Technology)

  • Shinji Irie

    (Joint Research Laboratory (TOPPAN INC.) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University
    TOPPAN INC., Technical Research Institute)

  • Shiro Kitano

    (Joint Research Laboratory (TOPPAN INC.) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University
    TOPPAN INC., Technical Research Institute)

  • Michiya Matsusaki

    (Osaka University
    Joint Research Laboratory (TOPPAN INC.) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University)

Abstract

With the current interest in cultured meat, mammalian cell-based meat has mostly been unstructured. There is thus still a high demand for artificial steak-like meat. We demonstrate in vitro construction of engineered steak-like tissue assembled of three types of bovine cell fibers (muscle, fat, and vessel). Because actual meat is an aligned assembly of the fibers connected to the tendon for the actions of contraction and relaxation, tendon-gel integrated bioprinting was developed to construct tendon-like gels. In this study, a total of 72 fibers comprising 42 muscles, 28 adipose tissues, and 2 blood capillaries were constructed by tendon-gel integrated bioprinting and manually assembled to fabricate steak-like meat with a diameter of 5 mm and a length of 10 mm inspired by a meat cut. The developed tendon-gel integrated bioprinting here could be a promising technology for the fabrication of the desired types of steak-like cultured meats.

Suggested Citation

  • Dong-Hee Kang & Fiona Louis & Hao Liu & Hiroshi Shimoda & Yasutaka Nishiyama & Hajime Nozawa & Makoto Kakitani & Daisuke Takagi & Daijiro Kasa & Eiji Nagamori & Shinji Irie & Shiro Kitano & Michiya Ma, 2021. "Engineered whole cut meat-like tissue by the assembly of cell fibers using tendon-gel integrated bioprinting," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25236-9
    DOI: 10.1038/s41467-021-25236-9
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    Cited by:

    1. Gaoxiang Zhu & Dengfeng Gao & Linzi Li & Yixuan Yao & Yingjie Wang & Minglei Zhi & Jinying Zhang & Xinze Chen & Qianqian Zhu & Jie Gao & Tianzhi Chen & Xiaowei Zhang & Tong Wang & Suying Cao & Aijin M, 2023. "Generation of three-dimensional meat-like tissue from stable pig epiblast stem cells," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Milae Lee & Sohyeon Park & Bumgyu Choi & Woojin Choi & Hyun Lee & Jeong Min Lee & Seung Tae Lee & Ki Hyun Yoo & Dongoh Han & Geul Bang & Heeyoun Hwang & Won-Gun Koh & Sangmin Lee & Jinkee Hong, 2024. "Cultured meat with enriched organoleptic properties by regulating cell differentiation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Ye Liu & Anqi Gao & Tiantian Wang & Yongqian Zhang & Gaoxiang Zhu & Sida Ling & Zhaozhao Wu & Yuhong Jin & Haoke Chen & Yuming Lai & Rui Zhang & Yuchen Yang & Jianyong Han & Yulin Deng & Yanan Du, 2025. "Growing meat on autoclaved vegetables with biomimetic stiffness and micro-patterns," Nature Communications, Nature, vol. 16(1), pages 1-16, December.

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