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An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination

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  • Yongchao Wang

    (China Pharmaceutical University
    Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Ningqiang Gong

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Chi Ma

    (China Pharmaceutical University)

  • Yuxuan Zhang

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Hong Tan

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences
    Guangxi Medical University)

  • Guangchao Qing

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Jimei Zhang

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Yufei Wang

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Jinjin Wang

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Shizhu Chen

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Xianlei Li

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Qiankun Ni

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Yuan Yuan

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Yaling Gan

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Junge Chen

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Fangzhou Li

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

  • Jinchao Zhang

    (Hebei University)

  • Caiwen Ou

    (Dongguan Hospital of Southern Medical University, Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation)

  • Yongxiang Zhao

    (Guangxi Medical University)

  • Xiaoxuan Liu

    (China Pharmaceutical University)

  • Xing-Jie Liang

    (Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology
    University of Chinese Academy of Sciences)

Abstract

Immunological adjuvants are essential for successful cancer vaccination. However, traditional adjuvants have some limitations, such as lack of controllability and induction of systemic toxicity, which restrict their broad application. Here, we present a light-activable immunological adjuvant (LIA), which is composed of a hypoxia-responsive amphiphilic dendrimer nanoparticle loaded with chlorin e6. Under irradiation with near-infrared light, the LIA not only induces tumour cell lysis and tumour antigen release, but also promotes the structural transformation of 2-nitroimidazole containing dendrimer to 2-aminoimidazole containing dendrimer which can activate dendritic cells via the Toll-like receptor 7-mediated signaling pathway. The LIA efficiently inhibits both primary and abscopal tumour growth and induces strong antigen-specific immune memory effect to prevent tumour metastasis and recurrence in vivo. Furthermore, LIA localizes the immunological adjuvant effect at the tumour site. We demonstrate this light-activable immunological adjuvant offers a safe and potent platform for in situ cancer vaccination.

Suggested Citation

  • Yongchao Wang & Ningqiang Gong & Chi Ma & Yuxuan Zhang & Hong Tan & Guangchao Qing & Jimei Zhang & Yufei Wang & Jinjin Wang & Shizhu Chen & Xianlei Li & Qiankun Ni & Yuan Yuan & Yaling Gan & Junge Che, 2021. "An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25197-z
    DOI: 10.1038/s41467-021-25197-z
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    Cited by:

    1. Dongsheng Tang & Minhui Cui & Bin Wang & Ganghao Liang & Hanchen Zhang & Haihua Xiao, 2024. "Nanoparticles destabilizing the cell membranes triggered by NIR light for cancer imaging and photo-immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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