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The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients

Author

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  • Matthieu Perreau

    (Lausanne University Hospital, University of Lausanne)

  • Madeleine Suffiotti

    (Lausanne University Hospital, University of Lausanne)

  • Pedro Marques-Vidal

    (Lausanne University Hospital, University of Lausanne)

  • Aurelie Wiedemann

    (Université Paris-Est, Faculté de Médecine, INSERM U955
    Service d’Immunologie Clinique)

  • Yves Levy

    (Université Paris-Est, Faculté de Médecine, INSERM U955
    Service d’Immunologie Clinique)

  • Cédric Laouénan

    (AP-HP, Hôpital Bichat, Département Épidémiologie Biostatistiques et Recherche Clinique, INSERM, Centre d’Investigation clinique-Epidémiologie Clinique 1425
    Université de Paris, INSERM, IAME UMR 1137)

  • Jade Ghosn

    (AP-HP, Hôpital Bichat, Service de Maladies Infectieuses et Tropicales)

  • Craig Fenwick

    (Lausanne University Hospital, University of Lausanne)

  • Denis Comte

    (Lausanne University Hospital, University of Lausanne)

  • Thierry Roger

    (Lausanne University Hospital, University of Lausanne)

  • Jean Regina

    (Lausanne University Hospital, University of Lausanne)

  • Peter Vollenweider

    (Lausanne University Hospital, University of Lausanne)

  • Gerard Waeber

    (Lausanne University Hospital, University of Lausanne)

  • Mauro Oddo

    (Lausanne University Hospital, University of Lausanne)

  • Thierry Calandra

    (Lausanne University Hospital, University of Lausanne)

  • Giuseppe Pantaleo

    (Lausanne University Hospital, University of Lausanne
    Université Paris-Est, Faculté de Médecine, INSERM U955
    Lausanne University Hospital, University of Lausanne)

Abstract

The objective of the present study was to identify biological signatures of severe coronavirus disease 2019 (COVID-19) predictive of admission in the intensive care unit (ICU). Over 170 immunological markers were investigated in a ‘discovery’ cohort (n = 98 patients) of the Lausanne University Hospital (LUH-1). Here we report that 13 out of 49 cytokines were significantly associated with ICU admission in the three cohorts (P

Suggested Citation

  • Matthieu Perreau & Madeleine Suffiotti & Pedro Marques-Vidal & Aurelie Wiedemann & Yves Levy & Cédric Laouénan & Jade Ghosn & Craig Fenwick & Denis Comte & Thierry Roger & Jean Regina & Peter Vollenwe, 2021. "The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25191-5
    DOI: 10.1038/s41467-021-25191-5
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    Cited by:

    1. Benedict D. Michael & Cordelia Dunai & Edward J. Needham & Kukatharmini Tharmaratnam & Robyn Williams & Yun Huang & Sarah A. Boardman & Jordan J. Clark & Parul Sharma & Krishanthi Subramaniam & Greta , 2023. "Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Manina M. Etter & Tomás A. Martins & Laila Kulsvehagen & Elisabeth Pössnecker & Wandrille Duchemin & Sabrina Hogan & Gretel Sanabria-Diaz & Jannis Müller & Alessio Chiappini & Jonathan Rychen & Noëmi , 2022. "Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    3. Victor Joo & Karim Abdelhamid & Alessandra Noto & Sofiya Latifyan & Federica Martina & Douglas Daoudlarian & Rita De Micheli & Menno Pruijm & Solange Peters & Roger Hullin & Olivier Gaide & Giuseppe P, 2024. "Primary prophylaxis with mTOR inhibitor enhances T cell effector function and prevents heart transplant rejection during talimogene laherparepvec therapy of squamous cell carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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