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Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord

Author

Listed:
  • Weipang Chang

    (Karolinska Institutet)

  • Andrea Pedroni

    (Karolinska Institutet)

  • Maria Bertuzzi

    (Karolinska Institutet)

  • Caghan Kizil

    (German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association
    Columbia University Irving Medical Center)

  • András Simon

    (Karolinska Institutet)

  • Konstantinos Ampatzis

    (Karolinska Institutet)

Abstract

Physical exercise stimulates adult neurogenesis, yet the underlying mechanisms remain poorly understood. A fundamental component of the innate neuroregenerative capacity of zebrafish is the proliferative and neurogenic ability of the neural stem/progenitor cells. Here, we show that in the intact spinal cord, this plasticity response can be activated by physical exercise by demonstrating that the cholinergic neurotransmission from spinal locomotor neurons activates spinal neural stem/progenitor cells, leading to neurogenesis in the adult zebrafish. We also show that GABA acts in a non-synaptic fashion to maintain neural stem/progenitor cell quiescence in the spinal cord and that training-induced activation of neurogenesis requires a reduction of GABAA receptors. Furthermore, both pharmacological stimulation of cholinergic receptors, as well as interference with GABAergic signaling, promote functional recovery after spinal cord injury. Our findings provide a model for locomotor networks’ activity-dependent neurogenesis during homeostasis and regeneration in the adult zebrafish spinal cord.

Suggested Citation

  • Weipang Chang & Andrea Pedroni & Maria Bertuzzi & Caghan Kizil & András Simon & Konstantinos Ampatzis, 2021. "Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25052-1
    DOI: 10.1038/s41467-021-25052-1
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    Cited by:

    1. Andrea Pedroni & Yu-Wen E. Dai & Leslie Lafouasse & Weipang Chang & Ipsit Srivastava & Lisa Vecchio & Konstantinos Ampatzis, 2024. "Neuroprotective gap-junction-mediated bystander transformations in the adult zebrafish spinal cord after injury," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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