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The physiological basis for contrast opponency in motion computation in Drosophila

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  • Giordano Ramos-Traslosheros

    (Johannes-Gutenberg University Mainz
    International Max Planck Research School Neuroscienes and Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences (GGNB) at the University of Göttingen)

  • Marion Silies

    (Johannes-Gutenberg University Mainz)

Abstract

In Drosophila, direction-selective neurons implement a mechanism of motion computation similar to cortical neurons, using contrast-opponent receptive fields with ON and OFF subfields. It is not clear how the presynaptic circuitry of direction-selective neurons in the OFF pathway supports this computation if all major inputs are OFF-rectified neurons. Here, we reveal the biological substrate for motion computation in the OFF pathway. Three interneurons, Tm2, Tm9 and CT1, provide information about ON stimuli to the OFF direction-selective neuron T5 across its receptive field, supporting a contrast-opponent receptive field organization. Consistent with its prominent role in motion detection, variability in Tm9 receptive field properties transfers to T5, and calcium decrements in Tm9 in response to ON stimuli persist across behavioral states, while spatial tuning is sharpened by active behavior. Together, our work shows how a key neuronal computation is implemented by its constituent neuronal circuit elements to ensure direction selectivity.

Suggested Citation

  • Giordano Ramos-Traslosheros & Marion Silies, 2021. "The physiological basis for contrast opponency in motion computation in Drosophila," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24986-w
    DOI: 10.1038/s41467-021-24986-w
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    Cited by:

    1. Jacqueline Cornean & Sebastian Molina-Obando & Burak Gür & Annika Bast & Giordano Ramos-Traslosheros & Jonas Chojetzki & Lena Lörsch & Maria Ioannidou & Rachita Taneja & Christopher Schnaitmann & Mari, 2024. "Heterogeneity of synaptic connectivity in the fly visual system," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Kit D. Longden & Edward M. Rogers & Aljoscha Nern & Heather Dionne & Michael B. Reiser, 2023. "Different spectral sensitivities of ON- and OFF-motion pathways enhance the detection of approaching color objects in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    3. Burak Gür & Luisa Ramirez & Jacqueline Cornean & Freya Thurn & Sebastian Molina-Obando & Giordano Ramos-Traslosheros & Marion Silies, 2024. "Neural pathways and computations that achieve stable contrast processing tuned to natural scenes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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