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Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function

Author

Listed:
  • L. Grevendonk

    (Maastricht University
    TI Food and Nutrition)

  • N. J. Connell

    (Maastricht University
    TI Food and Nutrition)

  • C. McCrum

    (Maastricht University)

  • C. E. Fealy

    (Maastricht University
    TI Food and Nutrition)

  • L. Bilet

    (Maastricht University
    TI Food and Nutrition)

  • Y. M. H. Bruls

    (Maastricht University Medical Center+)

  • J. Mevenkamp

    (Maastricht University Medical Center+)

  • V. B. Schrauwen-Hinderling

    (Maastricht University
    Maastricht University Medical Center+)

  • J. A. Jörgensen

    (Maastricht University)

  • E. Moonen-Kornips

    (Maastricht University)

  • G. Schaart

    (Maastricht University)

  • B. Havekes

    (Maastricht University
    Maastricht University Medical Center+)

  • J. Vogel-van den Bosch

    (Danone Nutricia Research)

  • M. C. E. Bragt

    (Friesland-Campina)

  • K. Meijer

    (Maastricht University)

  • P. Schrauwen

    (Maastricht University
    TI Food and Nutrition)

  • J. Hoeks

    (Maastricht University
    TI Food and Nutrition)

Abstract

The relationship between the age-associated decline in mitochondrial function and its effect on skeletal muscle physiology and function remain unclear. In the current study, we examined to what extent physical activity contributes to the decline in mitochondrial function and muscle health during aging and compared mitochondrial function in young and older adults, with similar habitual physical activity levels. We also studied exercise-trained older adults and physically impaired older adults. Aging was associated with a decline in mitochondrial capacity, exercise capacity and efficiency, gait stability, muscle function, and insulin sensitivity, even when maintaining an adequate daily physical activity level. Our data also suggest that a further increase in physical activity level, achieved through regular exercise training, can largely negate the effects of aging. Finally, mitochondrial capacity correlated with exercise efficiency and insulin sensitivity. Together, our data support a link between mitochondrial function and age-associated deterioration of skeletal muscle.

Suggested Citation

  • L. Grevendonk & N. J. Connell & C. McCrum & C. E. Fealy & L. Bilet & Y. M. H. Bruls & J. Mevenkamp & V. B. Schrauwen-Hinderling & J. A. Jörgensen & E. Moonen-Kornips & G. Schaart & B. Havekes & J. Vog, 2021. "Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24956-2
    DOI: 10.1038/s41467-021-24956-2
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    Cited by:

    1. Wang, Qiang & Zhang, Chen & Li, Rongrong, 2022. "Towards carbon neutrality by improving carbon efficiency - A system-GMM dynamic panel analysis for 131 countries’ carbon efficiency," Energy, Elsevier, vol. 258(C).
    2. Julian Mevenkamp & Yvonne M. H. Bruls & Rodrigo Mancilla & Lotte Grevendonk & Joachim E. Wildberger & Kim Brouwers & Matthijs K. C. Hesselink & Patrick Schrauwen & Joris Hoeks & Riekelt H. Houtkooper , 2024. "Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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