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Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

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  • Burair A. Alsaihati

    (University of Georgia
    King Abdulaziz City for Science and Technology)

  • Kun-Lin Ho

    (University of Georgia)

  • Joshua Watson

    (University of Georgia)

  • Yuan Feng

    (University of Georgia)

  • Tianfang Wang

    (University of Georgia)

  • Kevin K. Dobbin

    (University of Georgia)

  • Shaying Zhao

    (University of Georgia)

Abstract

Spontaneous canine cancers are valuable but relatively understudied and underutilized models. To enhance their usage, we reanalyze whole exome and genome sequencing data published for 684 cases of >7 common tumor types and >35 breeds, with rigorous quality control and breed validation. Our results indicate that canine tumor alteration landscape is tumor type-dependent, but likely breed-independent. Each tumor type harbors major pathway alterations also found in its human counterpart (e.g., PI3K in mammary tumor and p53 in osteosarcoma). Mammary tumor and glioma have lower tumor mutational burden (TMB) (median

Suggested Citation

  • Burair A. Alsaihati & Kun-Lin Ho & Joshua Watson & Yuan Feng & Tianfang Wang & Kevin K. Dobbin & Shaying Zhao, 2021. "Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24836-9
    DOI: 10.1038/s41467-021-24836-9
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