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Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery

Author

Listed:
  • Dashuai Zhu

    (College of Life Sciences, Nankai University
    Nankai University)

  • Jingli Hou

    (Tianjin Medical University)

  • Meng Qian

    (College of Life Sciences, Nankai University)

  • Dawei Jin

    (Shanghai Jiao Tong University)

  • Tian Hao

    (College of Life Sciences, Nankai University)

  • Yanjun Pan

    (Shanghai Jiao Tong University)

  • He Wang

    (College of Life Sciences, Nankai University)

  • Shuting Wu

    (Shanghai Jiao Tong University)

  • Shuo Liu

    (Nankai University)

  • Fei Wang

    (College of Life Sciences, Nankai University)

  • Lanping Wu

    (Shanghai Jiao Tong University)

  • Yumin Zhong

    (Shanghai Jiao Tong University)

  • Zhilu Yang

    (Southwest Jiaotong University)

  • Yongzhe Che

    (Nankai University)

  • Jie Shen

    (Nankai University)

  • Deling Kong

    (College of Life Sciences, Nankai University)

  • Meng Yin

    (Shanghai Jiao Tong University)

  • Qiang Zhao

    (College of Life Sciences, Nankai University
    Zhengzhou Cardiovascular Hospital and 7th People’s Hospital of Zhengzhou)

Abstract

Nitric oxide (NO) is a short-lived signaling molecule that plays a pivotal role in cardiovascular system. Organic nitrates represent a class of NO-donating drugs for treating coronary artery diseases, acting through the vasodilation of systemic vasculature that often leads to adverse effects. Herein, we design a nitrate-functionalized patch, wherein the nitrate pharmacological functional groups are covalently bound to biodegradable polymers, thus transforming small-molecule drugs into therapeutic biomaterials. When implanted onto the myocardium, the patch releases NO locally through a stepwise biotransformation, and NO generation is remarkably enhanced in infarcted myocardium because of the ischemic microenvironment, which gives rise to mitochondrial-targeted cardioprotection as well as enhanced cardiac repair. The therapeutic efficacy is further confirmed in a clinically relevant porcine model of myocardial infarction. All these results support the translational potential of this functional patch for treating ischemic heart disease by therapeutic mechanisms different from conventional organic nitrate drugs.

Suggested Citation

  • Dashuai Zhu & Jingli Hou & Meng Qian & Dawei Jin & Tian Hao & Yanjun Pan & He Wang & Shuting Wu & Shuo Liu & Fei Wang & Lanping Wu & Yumin Zhong & Zhilu Yang & Yongzhe Che & Jie Shen & Deling Kong & M, 2021. "Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24804-3
    DOI: 10.1038/s41467-021-24804-3
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    Cited by:

    1. Yuanxiong Cao & Jiayi Tan & Haoran Zhao & Ting Deng & Yunxia Hu & Junhong Zeng & Jiawei Li & Yifan Cheng & Jiyuan Tang & Zhiwei Hu & Keer Hu & Bing Xu & Zitian Wang & Yaojiong Wu & Peter E. Lobie & Sh, 2022. "Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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