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Towards a synthetic cell cycle

Author

Listed:
  • Lorenzo Olivi

    (Wageningen University)

  • Mareike Berger

    (Institute AMOLF)

  • Ramon N. P. Creyghton

    (Institute AMOLF)

  • Nicola De Franceschi

    (Delft University of Technology)

  • Cees Dekker

    (Delft University of Technology)

  • Bela M. Mulder

    (Institute AMOLF)

  • Nico J. Claassens

    (Wageningen University)

  • Pieter Rein ten Wolde

    (Institute AMOLF)

  • John van der Oost

    (Wageningen University)

Abstract

Recent developments in synthetic biology may bring the bottom-up generation of a synthetic cell within reach. A key feature of a living synthetic cell is a functional cell cycle, in which DNA replication and segregation as well as cell growth and division are well integrated. Here, we describe different approaches to recreate these processes in a synthetic cell, based on natural systems and/or synthetic alternatives. Although some individual machineries have recently been established, their integration and control in a synthetic cell cycle remain to be addressed. In this Perspective, we discuss potential paths towards an integrated synthetic cell cycle.

Suggested Citation

  • Lorenzo Olivi & Mareike Berger & Ramon N. P. Creyghton & Nicola De Franceschi & Cees Dekker & Bela M. Mulder & Nico J. Claassens & Pieter Rein ten Wolde & John van der Oost, 2021. "Towards a synthetic cell cycle," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24772-8
    DOI: 10.1038/s41467-021-24772-8
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    Cited by:

    1. Chen, Qi & Duan, Yongrui, 2023. "Impact of information disclosure on global supply chain greenwashing: Is more information transparency always better?," Transportation Research Part E: Logistics and Transportation Review, Elsevier, vol. 178(C).

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