IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-24717-1.html
   My bibliography  Save this article

Remote control of neural function by X-ray-induced scintillation

Author

Listed:
  • Takanori Matsubara

    (Nagoya University
    Nagoya University
    Fujita Health University School of Medicine)

  • Takayuki Yanagida

    (Nara Institute of Science and Technology)

  • Noriaki Kawaguchi

    (Nara Institute of Science and Technology)

  • Takashi Nakano

    (Nara Institute of Science and Technology
    Fujita Health University School of Medicine)

  • Junichiro Yoshimoto

    (Nara Institute of Science and Technology)

  • Maiko Sezaki

    (Kumamoto University)

  • Hitoshi Takizawa

    (Kumamoto University)

  • Satoshi P. Tsunoda

    (Nagoya Institute of Technology
    PRESTO, Japan Science and Technology Agency)

  • Shin-ichiro Horigane

    (Nagoya University
    Nagoya University)

  • Shuhei Ueda

    (Nagoya University
    Nagoya University)

  • Sayaka Takemoto-Kimura

    (Nagoya University
    Nagoya University)

  • Hideki Kandori

    (Nagoya Institute of Technology
    CREST, Japan Science and Technology Agency)

  • Akihiro Yamanaka

    (Nagoya University
    Nagoya University
    CREST, Japan Science and Technology Agency)

  • Takayuki Yamashita

    (Nagoya University
    Nagoya University
    Fujita Health University School of Medicine
    PRESTO, Japan Science and Technology Agency)

Abstract

Scintillators emit visible luminescence when irradiated with X-rays. Given the unlimited tissue penetration of X-rays, the employment of scintillators could enable remote optogenetic control of neural functions at any depth of the brain. Here we show that a yellow-emitting inorganic scintillator, Ce-doped Gd3(Al,Ga)5O12 (Ce:GAGG), can effectively activate red-shifted excitatory and inhibitory opsins, ChRmine and GtACR1, respectively. Using injectable Ce:GAGG microparticles, we successfully activated and inhibited midbrain dopamine neurons in freely moving mice by X-ray irradiation, producing bidirectional modulation of place preference behavior. Ce:GAGG microparticles are non-cytotoxic and biocompatible, allowing for chronic implantation. Pulsed X-ray irradiation at a clinical dose level is sufficient to elicit behavioral changes without reducing the number of radiosensitive cells in the brain and bone marrow. Thus, scintillator-mediated optogenetics enables minimally invasive, wireless control of cellular functions at any tissue depth in living animals, expanding X-ray applications to functional studies of biology and medicine.

Suggested Citation

  • Takanori Matsubara & Takayuki Yanagida & Noriaki Kawaguchi & Takashi Nakano & Junichiro Yoshimoto & Maiko Sezaki & Hitoshi Takizawa & Satoshi P. Tsunoda & Shin-ichiro Horigane & Shuhei Ueda & Sayaka T, 2021. "Remote control of neural function by X-ray-induced scintillation," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24717-1
    DOI: 10.1038/s41467-021-24717-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-24717-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-24717-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kyle Tucker & Savitha Sridharan & Hillel Adesnik & Stephen G. Brohawn, 2022. "Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24717-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.