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SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’

Author

Listed:
  • Ilaria Dorigatti

    (Imperial College London)

  • Enrico Lavezzo

    (University of Padova)

  • Laura Manuto

    (University of Padova)

  • Constanze Ciavarella

    (Imperial College London)

  • Monia Pacenti

    (Azienda Ospedale Padova)

  • Caterina Boldrin

    (Azienda Ospedale Padova)

  • Margherita Cattai

    (Azienda Ospedale Padova)

  • Francesca Saluzzo

    (University of Padova)

  • Elisa Franchin

    (University of Padova)

  • Claudia Del Vecchio

    (University of Padova)

  • Federico Caldart

    (University of Padova)

  • Gioele Castelli

    (University of Padova)

  • Michele Nicoletti

    (University of Padova)

  • Eleonora Nieddu

    (University of Padova)

  • Elisa Salvadoretti

    (University of Padova)

  • Beatrice Labella

    (University of Padova)

  • Ludovico Fava

    (University of Padova)

  • Simone Guglielmo

    (University of Padova)

  • Mariateresa Fascina

    (University of Padova)

  • Marco Grazioli

    (University of Padova)

  • Gualtiero Alvisi

    (University of Padova)

  • Maria Cristina Vanuzzo

    (Azienda Ospedale Padova)

  • Tiziano Zupo

    (Azienda Ospedale Padova)

  • Reginetta Calandrin

    (Azienda Ospedale Padova)

  • Vittoria Lisi

    (Azienda Ospedale Padova)

  • Lucia Rossi

    (Azienda Ospedale Padova)

  • Ignazio Castagliuolo

    (University of Padova)

  • Stefano Merigliano

    (University of Padova)

  • H. Juliette T. Unwin

    (Imperial College London)

  • Mario Plebani

    (University of Padova)

  • Andrea Padoan

    (University of Padova)

  • Alessandra R. Brazzale

    (University of Padova)

  • Stefano Toppo

    (University of Padova
    University of Padova)

  • Neil M. Ferguson

    (Imperial College London)

  • Christl A. Donnelly

    (Imperial College London
    University of Oxford)

  • Andrea Crisanti

    (University of Padova
    Azienda Ospedale Padova
    Department of Life Science Imperial College London, Exhibition Road)

Abstract

In February and March 2020, two mass swab testing campaigns were conducted in Vo’, Italy. In May 2020, we tested 86% of the Vo’ population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI): 2.8–4.3%) in May. In November, 98.8% (95% Confidence Interval (CI): 93.7–100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95% CI: 11.0–28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95% CrI: 17.2–36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression.

Suggested Citation

  • Ilaria Dorigatti & Enrico Lavezzo & Laura Manuto & Constanze Ciavarella & Monia Pacenti & Caterina Boldrin & Margherita Cattai & Francesca Saluzzo & Elisa Franchin & Claudia Del Vecchio & Federico Cal, 2021. "SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo’," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24622-7
    DOI: 10.1038/s41467-021-24622-7
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