IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-24591-x.html
   My bibliography  Save this article

FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

Author

Listed:
  • Vijayashree Mysore

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Xavier Cullere

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Joseph Mears

    (Brigham and Women’s Hospital
    Brigham and Women’s Hospital and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School)

  • Florencia Rosetti

    (Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán)

  • Koshu Okubo

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Pei X. Liew

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Fan Zhang

    (Brigham and Women’s Hospital
    Brigham and Women’s Hospital and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School)

  • Iris Madera-Salcedo

    (Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán)

  • Frank Rosenbauer

    (University of Muenster)

  • Richard M. Stone

    (Dana-Farber Cancer Institute and Harvard Medical School)

  • Jon C. Aster

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Ulrich H. von Andrian

    (Harvard Medical School)

  • Andrew H. Lichtman

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Soumya Raychaudhuri

    (Brigham and Women’s Hospital
    Brigham and Women’s Hospital and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School
    The University of Manchester)

  • Tanya N. Mayadas

    (Brigham and Women’s Hospital and Harvard Medical School)

Abstract

Classical dendritic cells (cDC) are professional antigen-presenting cells (APC) that regulate immunity and tolerance. Neutrophil-derived cells with properties of DCs (nAPC) are observed in human diseases and after culture of neutrophils with cytokines. Here we show that FcγR-mediated endocytosis of antibody-antigen complexes or an anti-FcγRIIIB-antigen conjugate converts neutrophils into nAPCs that, in contrast to those generated with cytokines alone, activate T cells to levels observed with cDCs and elicit CD8+ T cell-dependent anti-tumor immunity in mice. Single cell transcript analyses and validation studies implicate the transcription factor PU.1 in neutrophil to nAPC conversion. In humans, blood nAPC frequency in lupus patients correlates with disease. Moreover, anti-FcγRIIIB-antigen conjugate treatment induces nAPCs that can activate autologous T cells when using neutrophils from individuals with myeloid neoplasms that harbor neoantigens or those vaccinated against bacterial toxins. Thus, anti-FcγRIIIB-antigen conjugate-induced conversion of neutrophils to immunogenic nAPCs may represent a possible immunotherapy for cancer and infectious diseases.

Suggested Citation

  • Vijayashree Mysore & Xavier Cullere & Joseph Mears & Florencia Rosetti & Koshu Okubo & Pei X. Liew & Fan Zhang & Iris Madera-Salcedo & Frank Rosenbauer & Richard M. Stone & Jon C. Aster & Ulrich H. vo, 2021. "FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity," Nature Communications, Nature, vol. 12(1), pages 1-23, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24591-x
    DOI: 10.1038/s41467-021-24591-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-24591-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-24591-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Anissa El Marrahi & Fabio Lipreri & Ziqi Kang & Louise Gsell & Alper Eroglu & David Alber & Jean Hausser, 2023. "NIPMAP: niche-phenotype mapping of multiplex histology data by community ecology," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24591-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.