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Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers

Author

Listed:
  • Chandima Jeewandara

    (University of Sri Jayewardenepura)

  • Achala Kamaladasa

    (University of Sri Jayewardenepura)

  • Pradeep Darshana Pushpakumara

    (University of Sri Jayewardenepura)

  • Deshni Jayathilaka

    (University of Sri Jayewardenepura)

  • Inoka Sepali Aberathna

    (University of Sri Jayewardenepura)

  • Danasekara Rallage Saubhagya Rasikangani Danasekara

    (University of Sri Jayewardenepura)

  • Dinuka Guruge

    (Colombo Municipal Council)

  • Thushali Ranasinghe

    (University of Sri Jayewardenepura)

  • Shashika Dayarathna

    (University of Sri Jayewardenepura)

  • Thilagaraj Pathmanathan

    (University of Sri Jayewardenepura)

  • Gayasha Somathilake

    (University of Sri Jayewardenepura)

  • Panambara Arachchige Deshan Madhusanka

    (University of Sri Jayewardenepura)

  • Shyrar Tanussiya Ramu

    (University of Sri Jayewardenepura)

  • Tibutius Thanesh Pramanayagam Jayadas

    (University of Sri Jayewardenepura)

  • Heshan Kuruppu

    (University of Sri Jayewardenepura)

  • Ayesha Wijesinghe

    (University of Sri Jayewardenepura)

  • Herath Mudiyanselage Thashmi Nimasha

    (University of Sri Jayewardenepura)

  • Dushantha Milroy

    (Base Hospital)

  • Achini Anuja Nandasena

    (University of Sri Jayewardenepura)

  • Poththawela Kankanam Gamage Nilanka Sanjeewani

    (University of Sri Jayewardenepura)

  • Ruwan Wijayamuni

    (Colombo Municipal Council)

  • Sudath Samaraweera

    (Ministry of Health Sri Lanka)

  • Lisa Schimanski

    (University of Oxford
    University of Oxford)

  • T. K. Tan

    (University of Oxford
    University of Oxford)

  • Tao Dong

    (University of Oxford
    University of Oxford)

  • Graham S. Ogg

    (University of Oxford)

  • Alain Townsend

    (University of Oxford
    University of Oxford)

  • Gathsaurie Neelika Malavige

    (University of Sri Jayewardenepura
    University of Oxford)

Abstract

Several COVID-19 vaccines have received emergency approval. Here we assess the immunogenicity of a single dose of the AZD1222 vaccine, at one month, in a cohort of health care workers (HCWs) (629 naïve and 26 previously infected). 93.4% of naïve HCWs seroconverted, irrespective of age and gender. Haemagglutination test for antibodies to the receptor binding domain (RBD), surrogate neutralization assay (sVNT) and ex vivo IFNγ ELISpot assays were carried out in a sub-cohort. ACE2 blocking antibodies (measured by sVNT) were detected in 67/69 (97.1%) of naïve HCWs. Antibody levels to the RBD of the wild-type virus were higher than to RBD of B.1.1.7, and titres to B.1.351 were very low. Ex vivo T cell responses were observed in 30.8% to 61.7% in naïve HCWs. Previously infected HCWs, developed significantly higher (p

Suggested Citation

  • Chandima Jeewandara & Achala Kamaladasa & Pradeep Darshana Pushpakumara & Deshni Jayathilaka & Inoka Sepali Aberathna & Danasekara Rallage Saubhagya Rasikangani Danasekara & Dinuka Guruge & Thushali R, 2021. "Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24579-7
    DOI: 10.1038/s41467-021-24579-7
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