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Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

Author

Listed:
  • Todd M. Everson

    (Rollins School of Public Health at Emory University)

  • Marta Vives-Usano

    (Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra
    CIBER Epidemiología y Salud Pública (CIBERESP))

  • Emie Seyve

    (University Grenoble Alpes, Inserm, CNRS, IAB)

  • Andres Cardenas

    (Harvard Pilgrim Health Care Institute
    University of California, Berkeley)

  • Marina Lacasaña

    (CIBER Epidemiología y Salud Pública (CIBERESP)
    Andalusian School of Public Health
    Instituto de Investigación Biosantaria (ibs.GRANADA))

  • Jeffrey M. Craig

    (Murdoch Children’s Research Institute
    University of Melbourne
    Deakin University)

  • Corina Lesseur

    (Icahn School of Medicine at Mount Sinai)

  • Emily R. Baker

    (Geisel School of Medicine at Dartmouth College)

  • Nora Fernandez-Jimenez

    (University of the Basque Country (UPV/EHU)
    Biocruces-Bizkaia Health Research Institute
    Basque Government)

  • Barbara Heude

    (Université de Paris, CRESS, INSERM, INRAE)

  • Patrice Perron

    (University of Sherbrooke)

  • Beatriz Gónzalez-Alzaga

    (Andalusian School of Public Health
    Instituto de Investigación Biosantaria (ibs.GRANADA))

  • Jane Halliday

    (University of Melbourne
    Murdoch Children’s Research Institute)

  • Maya A. Deyssenroth

    (Icahn School of Medicine at Mount Sinai)

  • Margaret R. Karagas

    (Geisel School of Medicine at Dartmouth College)

  • Carmen Íñiguez

    (CIBER Epidemiología y Salud Pública (CIBERESP)
    Universitat de València
    FISABIO-Universitat Jaume I-Universitat de València)

  • Luigi Bouchard

    (University of Sherbrooke)

  • Pedro Carmona-Sáez

    (GENYO. Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government
    University of Granada)

  • Yuk J. Loke

    (Murdoch Children’s Research Institute
    University of Melbourne)

  • Ke Hao

    (Icahn School of Medicine at Mount Sinai)

  • Thalia Belmonte

    (IUOPA University of Oviedo)

  • Marie A. Charles

    (Université de Paris, CRESS, INSERM, INRAE)

  • Jordi Martorell-Marugán

    (GENYO. Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government
    Atrys Health S.A.)

  • Evelyne Muggli

    (University of Melbourne
    Murdoch Children’s Research Institute)

  • Jia Chen

    (Icahn School of Medicine at Mount Sinai)

  • Mariana F. Fernández

    (CIBER Epidemiología y Salud Pública (CIBERESP)
    Instituto de Investigación Biosantaria (ibs.GRANADA)
    University of Granada)

  • Jorg Tost

    (CEA – Institut de Biologie François Jacob)

  • Antonio Gómez-Martín

    (GENYO. Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government)

  • Stephanie J. London

    (National Institutes of Health, Department of Health and Human Services)

  • Jordi Sunyer

    (Universitat Pompeu Fabra
    CIBER Epidemiología y Salud Pública (CIBERESP)
    ISGlobal, Barcelona Institute for Global Health
    Hospital del Mar Medical Research Institute (IMIM))

  • Carmen J. Marsit

    (Rollins School of Public Health at Emory University
    Department of Epidemiology, Rollins School of Public health at Emory University)

  • Johanna Lepeule

    (University Grenoble Alpes, Inserm, CNRS, IAB)

  • Marie-France Hivert

    (Harvard Pilgrim Health Care Institute
    Diabetes Unit, Massachusetts General Hospital)

  • Mariona Bustamante

    (Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra
    CIBER Epidemiología y Salud Pública (CIBERESP)
    ISGlobal, Barcelona Institute for Global Health)

Abstract

Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.

Suggested Citation

  • Todd M. Everson & Marta Vives-Usano & Emie Seyve & Andres Cardenas & Marina Lacasaña & Jeffrey M. Craig & Corina Lesseur & Emily R. Baker & Nora Fernandez-Jimenez & Barbara Heude & Patrice Perron & Be, 2021. "Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24558-y
    DOI: 10.1038/s41467-021-24558-y
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    Cited by:

    1. Tammy C. Hartel & André Oelofse & Juléy J. A. De Smidt, 2023. "Vascular Effects, Potential Pathways and Mediators of Fetal Exposure to Alcohol and Cigarette Smoking during Pregnancy: A Narrative Review," IJERPH, MDPI, vol. 20(14), pages 1-19, July.

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