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A curved host and second guest cooperatively inhibit the dynamic motion of corannulene

Author

Listed:
  • Yang Yang

    (University of Cambridge
    Jiangsu Normal University)

  • Tanya K. Ronson

    (University of Cambridge)

  • Zifei Lu

    (University of Cambridge)

  • Jieyu Zheng

    (University of Cambridge)

  • Nicolas Vanthuyne

    (Aix Marseille Univ, CNRS, Centrale Marseille, iSm2)

  • Alexandre Martinez

    (Aix Marseille Univ, CNRS, Centrale Marseille, iSm2)

  • Jonathan R. Nitschke

    (University of Cambridge)

Abstract

Biomolecular systems show how host–guest binding can induce changes in molecular behavior, which in turn impact the functions of the system. Here we report an artificial host–guest system where dynamic adaptation during guest binding alters both host conformation and guest dynamics. The self-assembled cage host employed here possesses concave walls and a chirotopic cavity. Complementarity between the curved surfaces of fullerenes and the inner surface of the host cavity leads the host to reconfigure stereochemically in order to bind these guests optimally. The curved molecule corannulene undergoes rapid bowl-to-bowl inversion at room temperature. Its inversion barrier is increased upon binding, however, and increased further upon formation of a ternary complex, where corannulene and a cycloalkane are both bound together. The chiral nature of the host also leads to clear differences in the NMR spectra of ternary complexes involving corannulene and one or the other enantiomer of a chiral guest, which enables the determination of enantiomeric excess by NMR.

Suggested Citation

  • Yang Yang & Tanya K. Ronson & Zifei Lu & Jieyu Zheng & Nicolas Vanthuyne & Alexandre Martinez & Jonathan R. Nitschke, 2021. "A curved host and second guest cooperatively inhibit the dynamic motion of corannulene," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24344-w
    DOI: 10.1038/s41467-021-24344-w
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    Cited by:

    1. Shan Guo & Wen-Wen Zhan & Feng-Lei Yang & Jie Zhou & Yu-Hao Duan & Dawei Zhang & Yang Yang, 2024. "Enantiopure trigonal bipyramidal coordination cages templated by in situ self-organized D2h-symmetric anions," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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