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The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival

Author

Listed:
  • Sara Valpione

    (The University of Manchester
    Medical Oncology, The Christie NHS Foundation Trust)

  • Piyushkumar A. Mundra

    (The University of Manchester)

  • Elena Galvani

    (The University of Manchester)

  • Luca G. Campana

    (The Christie NHS Foundation Trust)

  • Paul Lorigan

    (Medical Oncology, The Christie NHS Foundation Trust)

  • Francesco Rosa

    (Immunotherapy - Cell Therapy and Biobank, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) “Dino Amadori” IRCCS)

  • Avinash Gupta

    (Medical Oncology, The Christie NHS Foundation Trust)

  • John Weightman

    (The University of Manchester)

  • Sarah Mills

    (Manchester Cancer Research Centre Biobank, The Christie NHS Foundation Trust)

  • Nathalie Dhomen

    (The University of Manchester)

  • Richard Marais

    (The University of Manchester)

Abstract

Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.

Suggested Citation

  • Sara Valpione & Piyushkumar A. Mundra & Elena Galvani & Luca G. Campana & Paul Lorigan & Francesco Rosa & Avinash Gupta & John Weightman & Sarah Mills & Nathalie Dhomen & Richard Marais, 2021. "The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24343-x
    DOI: 10.1038/s41467-021-24343-x
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