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Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV

Author

Listed:
  • Leila B. Giron

    (The Wistar Institute)

  • Clovis S. Palmer

    (The Burnet Institute
    Monash University)

  • Qin Liu

    (The Wistar Institute)

  • Xiangfan Yin

    (The Wistar Institute)

  • Emmanouil Papasavvas

    (The Wistar Institute)

  • Radwa Sharaf

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Behzad Etemad

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Mohammad Damra

    (The Wistar Institute)

  • Aaron R. Goldman

    (The Wistar Institute)

  • Hsin-Yao Tang

    (The Wistar Institute)

  • Rowena Johnston

    (amfAR, The Foundation for AIDS Research)

  • Karam Mounzer

    (Philadelphia FIGHT)

  • Jay R. Kostman

    (Philadelphia FIGHT)

  • Pablo Tebas

    (University of Pennsylvania)

  • Alan Landay

    (Rush University)

  • Luis J. Montaner

    (The Wistar Institute)

  • Jeffrey M. Jacobson

    (Case Western Reserve University School of Medicine)

  • Jonathan Z. Li

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Mohamed Abdel-Mohsen

    (The Wistar Institute)

Abstract

Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the host pathways involved in post-ART HIV control. Here we report plasma glycomic and metabolic signatures of time-to-viral-rebound and probability-of-viral-remission using samples from two independent cohorts. These samples include a large number of post-treatment controllers, a rare population demonstrating sustained virologic suppression after ART-cessation. These signatures remain significant after adjusting for key demographic and clinical confounders. We also report mechanistic links between some of these biomarkers and HIV latency reactivation and/or myeloid inflammation in vitro. Finally, machine learning algorithms, based on selected sets of these biomarkers, predict time-to-viral-rebound with 74% capacity and probability-of-viral-remission with 97.5% capacity. In summary, we report non-invasive plasma biomarkers, with potential functional significance, that predict both the duration and probability of HIV remission after treatment interruption.

Suggested Citation

  • Leila B. Giron & Clovis S. Palmer & Qin Liu & Xiangfan Yin & Emmanouil Papasavvas & Radwa Sharaf & Behzad Etemad & Mohammad Damra & Aaron R. Goldman & Hsin-Yao Tang & Rowena Johnston & Karam Mounzer &, 2021. "Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24077-w
    DOI: 10.1038/s41467-021-24077-w
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    Cited by:

    1. Caroline Passaes & Delphine Desjardins & Anaïs Chapel & Valérie Monceaux & Julien Lemaitre & Adeline Mélard & Federico Perdomo-Celis & Cyril Planchais & Maël Gourvès & Nastasia Dimant & Annie David & , 2024. "Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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