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Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

Author

Listed:
  • Andrea Doni

    (IRCCS Humanitas Research Hospital, via Manzoni 56)

  • Raffaella Parente

    (IRCCS Humanitas Research Hospital, via Manzoni 56)

  • Ilaria Laface

    (IRCCS Humanitas Research Hospital, via Manzoni 56
    University of Ferrara, Ferrara)

  • Elena Magrini

    (IRCCS Humanitas Research Hospital, via Manzoni 56)

  • Cristina Cunha

    (University of Minho
    ICVS/3B’s-PT Government Associate Laboratory)

  • Federico Simone Colombo

    (IRCCS Humanitas Research Hospital, via Manzoni 56)

  • João F. Lacerda

    (Faculdade de Medicina de Lisboa
    Hospital de Santa Maria)

  • António Campos

    (Instituto Português de Oncologia do Porto)

  • Sarah N. Mapelli

    (IRCCS Humanitas Research Hospital, via Manzoni 56)

  • Francesca Petroni

    (IRCCS Humanitas Research Hospital, via Manzoni 56)

  • Rémi Porte

    (IRCCS Humanitas Research Hospital, via Manzoni 56)

  • Tilo Schorn

    (IRCCS Humanitas Research Hospital, via Manzoni 56)

  • Antonio Inforzato

    (IRCCS Humanitas Research Hospital, via Manzoni 56
    Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4)

  • Toine Mercier

    (University Hospitals Leuven
    Immunology and Transplantation, KU Leuven)

  • Katrien Lagrou

    (Immunology and Transplantation, KU Leuven
    University Hospitals Leuven)

  • Johan Maertens

    (University Hospitals Leuven
    Immunology and Transplantation, KU Leuven)

  • John D. Lambris

    (University of Pennsylvania)

  • Barbara Bottazzi

    (IRCCS Humanitas Research Hospital, via Manzoni 56)

  • Cecilia Garlanda

    (IRCCS Humanitas Research Hospital, via Manzoni 56
    Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4)

  • Marina Botto

    (Imperial College London)

  • Agostinho Carvalho

    (University of Minho
    ICVS/3B’s-PT Government Associate Laboratory)

  • Alberto Mantovani

    (IRCCS Humanitas Research Hospital, via Manzoni 56
    Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4
    Queen Mary University of London)

Abstract

Serum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs−/− mice show enhanced susceptibility to A. fumigatus infection. Murine and human SAP bound conidia, activate the complement cascade and enhance phagocytosis by neutrophils. Apcs−/− mice are defective in vivo in terms of recruitment of neutrophils and phagocytosis in the lungs. Opsonic activity of SAP is dependent on the classical pathway of complement activation. In immunosuppressed mice, SAP administration protects hosts against A. fumigatus infection and death. In the context of a study of hematopoietic stem-cell transplantation, genetic variation in the human APCS gene is associated with susceptibility to invasive pulmonary aspergillosis. Thus, SAP is a fluid phase pattern recognition molecule essential for resistance against A. fumigatus.

Suggested Citation

  • Andrea Doni & Raffaella Parente & Ilaria Laface & Elena Magrini & Cristina Cunha & Federico Simone Colombo & João F. Lacerda & António Campos & Sarah N. Mapelli & Francesca Petroni & Rémi Porte & Tilo, 2021. "Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24021-y
    DOI: 10.1038/s41467-021-24021-y
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    Cited by:

    1. Sarah Dellière & Camille Chauvin & Sarah Sze Wah Wong & Markus Gressler & Valentina Possetti & Raffaella Parente & Thierry Fontaine & Thomas Krüger & Olaf Kniemeyer & Jagadeesh Bayry & Agostinho Carva, 2024. "Interplay between host humoral pattern recognition molecules controls undue immune responses against Aspergillus fumigatus," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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