IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-23962-8.html
   My bibliography  Save this article

Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery

Author

Listed:
  • Erfan Dashtimoghadam

    (University of North Carolina at Chapel Hill)

  • Farahnaz Fahimipour

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Andrew N. Keith

    (University of North Carolina at Chapel Hill)

  • Foad Vashahi

    (University of North Carolina at Chapel Hill)

  • Pavel Popryadukhin

    (Institute of Macromolecular Compounds of the Russian Academy of Sciences)

  • Mohammad Vatankhah-Varnosfaderani

    (University of North Carolina at Chapel Hill)

  • Sergei S. Sheiko

    (University of North Carolina at Chapel Hill)

Abstract

Current materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.

Suggested Citation

  • Erfan Dashtimoghadam & Farahnaz Fahimipour & Andrew N. Keith & Foad Vashahi & Pavel Popryadukhin & Mohammad Vatankhah-Varnosfaderani & Sergei S. Sheiko, 2021. "Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23962-8
    DOI: 10.1038/s41467-021-23962-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-23962-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-23962-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Pengfei Xu & Shaojia Wang & Angela Lin & Hyun-Kee Min & Zhanfeng Zhou & Wenkun Dou & Yu Sun & Xi Huang & Helen Tran & Xinyu Liu, 2023. "Conductive and elastic bottlebrush elastomers for ultrasoft electronics," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23962-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.