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Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2

Author

Listed:
  • Niclas Roxhed

    (KTH Royal Institute of Technology
    Karolinska University Hospital)

  • Annika Bendes

    (KTH Royal Institute of Technology)

  • Matilda Dale

    (KTH Royal Institute of Technology)

  • Cecilia Mattsson

    (KTH Royal Institute of Technology)

  • Leo Hanke

    (Karolinska Institutet)

  • Tea Dodig-Crnković

    (KTH Royal Institute of Technology)

  • Murray Christian

    (Karolinska Institutet)

  • Birthe Meineke

    (Division of Genome Biology
    Karolinska Institutet)

  • Simon Elsässer

    (Division of Genome Biology
    Karolinska Institutet)

  • Juni Andréll

    (Stockholm University)

  • Sebastian Havervall

    (Danderyd Hospital)

  • Charlotte Thålin

    (Danderyd Hospital)

  • Carina Eklund

    (Karolinska University Hospital)

  • Joakim Dillner

    (Karolinska University Hospital)

  • Olof Beck

    (Karolinska Institutet)

  • Cecilia E. Thomas

    (KTH Royal Institute of Technology)

  • Gerald McInerney

    (Karolinska Institutet)

  • Mun-Gwan Hong

    (KTH Royal Institute of Technology)

  • Ben Murrell

    (Karolinska Institutet)

  • Claudia Fredolini

    (KTH Royal Institute of Technology)

  • Jochen M. Schwenk

    (KTH Royal Institute of Technology)

Abstract

Serological testing is essential to curb the consequences of the COVID-19 pandemic. However, most assays are still limited to single analytes and samples collected within healthcare. Thus, we establish a multianalyte and multiplexed approach to reliably profile IgG and IgM levels against several versions of SARS-CoV-2 proteins (S, RBD, N) in home-sampled dried blood spots (DBS). We analyse DBS collected during spring of 2020 from 878 random and undiagnosed individuals from the population in Stockholm, Sweden, and use classification approaches to estimate an accumulated seroprevalence of 12.5% (95% CI: 10.3%–14.7%). This includes 5.4% of the samples being IgG+IgM+ against several SARS-CoV-2 proteins, as well as 2.1% being IgG−IgM+ and 5.0% being IgG+IgM− for the virus’ S protein. Subjects classified as IgG+ for several SARS-CoV-2 proteins report influenza-like symptoms more frequently than those being IgG+ for only the S protein (OR = 6.1; p

Suggested Citation

  • Niclas Roxhed & Annika Bendes & Matilda Dale & Cecilia Mattsson & Leo Hanke & Tea Dodig-Crnković & Murray Christian & Birthe Meineke & Simon Elsässer & Juni Andréll & Sebastian Havervall & Charlotte , 2021. "Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23893-4
    DOI: 10.1038/s41467-021-23893-4
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