IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-23462-9.html
   My bibliography  Save this article

Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes

Author

Listed:
  • Nikolaos Kaplaneris

    (Georg-August-Universität Göttingen)

  • Jongwoo Son

    (Georg-August-Universität Göttingen)

  • Lorena Mendive-Tapia

    (The University of Edinburgh)

  • Adelina Kopp

    (Georg-August-Universität Göttingen)

  • Nicole D. Barth

    (The University of Edinburgh)

  • Isaac Maksso

    (Georg-August-Universität Göttingen)

  • Marc Vendrell

    (The University of Edinburgh)

  • Lutz Ackermann

    (Georg-August-Universität Göttingen
    German Centre for Cardiovascular Research (DZHK))

Abstract

Bioorthogonal late-stage diversification of amino acids and peptides bears enormous potential for drug discovery and molecular imaging. Despite major accomplishments, these strategies largely rely on traditional, lengthy prefunctionalization methods, heavily involving precious transition-metal catalysis. Herein, we report on a resource-economical manganese(I)-catalyzed C–H fluorescent labeling of structurally complex peptides ensured by direct alkynylation and alkenylation manifolds. This modular strategy sets the stage for unraveling structure-activity relationships between structurally discrete fluorophores towards the rational design of BODIPY fluorogenic probes for real-time analysis of immune cell function.

Suggested Citation

  • Nikolaos Kaplaneris & Jongwoo Son & Lorena Mendive-Tapia & Adelina Kopp & Nicole D. Barth & Isaac Maksso & Marc Vendrell & Lutz Ackermann, 2021. "Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23462-9
    DOI: 10.1038/s41467-021-23462-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-23462-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-23462-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23462-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.