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Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis

Author

Listed:
  • Yuki Horisawa-Takada

    (Kumamoto University)

  • Chisato Kodera

    (Kumamoto University
    Kumamoto University)

  • Kazumasa Takemoto

    (Kumamoto University)

  • Akihiko Sakashita

    (Keio University School of Medicine)

  • Kenichi Horisawa

    (Kyushu University)

  • Ryo Maeda

    (Osaka University)

  • Ryuki Shimada

    (Kumamoto University)

  • Shingo Usuki

    (Kumamoto University)

  • Sayoko Fujimura

    (Kumamoto University)

  • Naoki Tani

    (Kumamoto University)

  • Kumi Matsuura

    (Kumamoto University)

  • Tomohiko Akiyama

    (Keio University School of Medicine)

  • Atsushi Suzuki

    (Kyushu University)

  • Hitoshi Niwa

    (Kumamoto University)

  • Makoto Tachibana

    (Osaka University)

  • Takashi Ohba

    (Kumamoto University)

  • Hidetaka Katabuchi

    (Kumamoto University)

  • Satoshi H. Namekawa

    (University of California)

  • Kimi Araki

    (Kumamoto University)

  • Kei-Ichiro Ishiguro

    (Kumamoto University)

Abstract

During spermatogenesis, meiosis is accompanied by a robust alteration in gene expression and chromatin status. However, it remains elusive how the meiotic transcriptional program is established to ensure completion of meiotic prophase. Here, we identify a protein complex that consists of germ-cell-specific zinc-finger protein ZFP541 and its interactor KCTD19 as the key transcriptional regulators in mouse meiotic prophase progression. Our genetic study shows that ZFP541 and KCTD19 are co-expressed from pachytene onward and play an essential role in the completion of the meiotic prophase program in the testis. Furthermore, our ChIP-seq and transcriptome analyses identify that ZFP541 binds to and suppresses a broad range of genes whose function is associated with biological processes of transcriptional regulation and covalent chromatin modification. The present study demonstrates that a germ-cell specific complex that contains ZFP541 and KCTD19 promotes the progression of meiotic prophase towards completion in male mice, and triggers the reconstruction of the transcriptional network and chromatin organization leading to post-meiotic development.

Suggested Citation

  • Yuki Horisawa-Takada & Chisato Kodera & Kazumasa Takemoto & Akihiko Sakashita & Kenichi Horisawa & Ryo Maeda & Ryuki Shimada & Shingo Usuki & Sayoko Fujimura & Naoki Tani & Kumi Matsuura & Tomohiko Ak, 2021. "Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23378-4
    DOI: 10.1038/s41467-021-23378-4
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    Cited by:

    1. Saori Yoshimura & Ryuki Shimada & Koji Kikuchi & Soichiro Kawagoe & Hironori Abe & Sakie Iisaka & Sayoko Fujimura & Kei-ichiro Yasunaga & Shingo Usuki & Naoki Tani & Takashi Ohba & Eiji Kondoh & Tomoh, 2024. "Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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