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Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer

Author

Listed:
  • Jieti Wang

    (Fudan University
    Fudan University
    Fudan University
    Nanjing Medical University)

  • Ruochen Li

    (Fudan University)

  • Yifan Cao

    (Fudan University)

  • Yun Gu

    (Fudan University)

  • Hanji Fang

    (Fudan University)

  • Yuchao Fei

    (Fudan University)

  • Kunpeng Lv

    (Fudan University)

  • Xudong He

    (Fudan University)

  • Chao Lin

    (Fudan University)

  • Hao Liu

    (Fudan University)

  • Heng Zhang

    (Fudan University)

  • He Li

    (Fudan University)

  • Hongyong He

    (Fudan University)

  • Jiejie Xu

    (Fudan University)

  • Hua Huang

    (Fudan University
    Fudan University
    Fudan University
    Nanjing Medical University)

Abstract

Studies that examined an association between CD8+T and prognosis in gastric cancer are inconsistent, and a distinct population of CXCR5+CD8+T associated with better overall survival has been reported among various malignancies. Here, we show that the abundance of intratumoral CXCR5+CD8+T cells is associated with better overall survival in patients with gastric cancer. Patients with TNM II + III gastric cancer with higher intratumoral CXCR5+CD8+T cell infiltration are more likely to benefit from adjuvant chemotherapy. Microsatellite-unstable and Epstein–Barr virus positive tumors are enriched with CXCR5+CD8+T cells. Gastric cancer infiltrating CXCR5+CD8+T cells represent a specific subtype of stem-like CD8+T with effector memory feature. Identification of the clinical significance and phenotype of gastric cancer infiltrating CXCR5+CD8+T provides a roadmap for patient stratification and trials of targeted therapies.

Suggested Citation

  • Jieti Wang & Ruochen Li & Yifan Cao & Yun Gu & Hanji Fang & Yuchao Fei & Kunpeng Lv & Xudong He & Chao Lin & Hao Liu & Heng Zhang & He Li & Hongyong He & Jiejie Xu & Hua Huang, 2021. "Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23356-w
    DOI: 10.1038/s41467-021-23356-w
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