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The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction

Author

Listed:
  • Fabiana Heredia

    (Universidade Nova de Lisboa)

  • Yanel Volonté

    (Universidade Nova de Lisboa
    Universidad Nacional del Sur - CONICET)

  • Joana Pereirinha

    (Universidade Nova de Lisboa
    Institute of Molecular Biology)

  • Magdalena Fernandez-Acosta

    (Universidade Nova de Lisboa)

  • Andreia P. Casimiro

    (Universidade Nova de Lisboa)

  • Cláudia G. Belém

    (Universidade Nova de Lisboa
    The Francis Crick Institute)

  • Filipe Viegas

    (Universidade Nova de Lisboa
    University of Zurich)

  • Kohtaro Tanaka

    (Instituto Gulbenkian de Ciências
    Fred Hutchinson Cancer Research Center)

  • Juliane Menezes

    (Universidade Nova de Lisboa)

  • Maite Arana

    (Universidad Nacional del Sur - CONICET)

  • Gisele A. Cardoso

    (Universidade Nova de Lisboa
    Universidade de São Paulo
    CBMEG, Universidade Estadual de Campinas)

  • André Macedo

    (Universidade Nova de Lisboa)

  • Malwina Kotowicz

    (Universidade Nova de Lisboa
    DZNE, Helmholtz Association)

  • Facundo H. Prado Spalm

    (Universidad Nacional del Sur - CONICET)

  • Marcos J. Dibo

    (Universidad Nacional del Sur - CONICET)

  • Raquel D. Monfardini

    (Universidade Nova de Lisboa
    Universidade de São Paulo)

  • Tatiana T. Torres

    (Universidade de São Paulo)

  • César S. Mendes

    (Universidade Nova de Lisboa)

  • Andres Garelli

    (Universidade Nova de Lisboa
    Universidad Nacional del Sur - CONICET)

  • Alisson M. Gontijo

    (Universidade Nova de Lisboa
    Rua do Instituto Bacteriológico 5, 1150-190)

Abstract

Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood. Here, we provide insight into these mechanisms by studying pupariation, a multi-step innate behavior of Drosophila larvae that is critical for survival during metamorphosis. We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Dilp8 acts on six Lgr3-positive thoracic interneurons to couple both subprograms in time and to instruct neuromotor subprogram switching during behavior. Our work reveals that interorgan feedback gates progression between subunits of an innate behavior and points to an ancestral neuromodulatory function of relaxin signaling.

Suggested Citation

  • Fabiana Heredia & Yanel Volonté & Joana Pereirinha & Magdalena Fernandez-Acosta & Andreia P. Casimiro & Cláudia G. Belém & Filipe Viegas & Kohtaro Tanaka & Juliane Menezes & Maite Arana & Gisele A. Ca, 2021. "The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23218-5
    DOI: 10.1038/s41467-021-23218-5
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    Cited by:

    1. D. Blanco-Obregon & K. El Marzkioui & F. Brutscher & V. Kapoor & L. Valzania & D. S. Andersen & J. Colombani & S. Narasimha & D. McCusker & P. Léopold & L. Boulan, 2022. "A Dilp8-dependent time window ensures tissue size adjustment in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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