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Quality control of protein reagents for the improvement of research data reproducibility

Author

Listed:
  • Ario Marco

    (University of Nova Gorica, Vipava)

  • Nick Berrow

    (The Barcelona Institute of Science and Technology)

  • Mario Lebendiker

    (Edmund J. Safra Campus - The Hebrew University of Jerusalem)

  • Maria Garcia-Alai

    (European Molecular Biology Laboratory (EMBL), Hamburg Outstation)

  • Stefan H. Knauer

    (University of Bayreuth)

  • Blanca Lopez-Mendez

    (Novo Nordisk Foundation Center for Protein Research)

  • André Matagne

    (University of Liège)

  • Annabel Parret

    (European Molecular Biology Laboratory (EMBL), Hamburg Outstation)

  • Kim Remans

    (Protein Expression and Purification Core Facility, EMBL Heidelberg)

  • Stephan Uebel

    (Charles River Laboratories)

  • Bertrand Raynal

    (Institut Pasteur, Plateforme de Biophysique moléculaire, Department of Structural Biology and Chemistry)

Abstract

Proteins and peptides are amongst the most widely used research reagents but often their quality is inadequate and can result in poor data reproducibility. Here we propose a simple set of guidelines that, when correctly applied to protein reagents should provide more reliable experimental data.

Suggested Citation

  • Ario Marco & Nick Berrow & Mario Lebendiker & Maria Garcia-Alai & Stefan H. Knauer & Blanca Lopez-Mendez & André Matagne & Annabel Parret & Kim Remans & Stephan Uebel & Bertrand Raynal, 2021. "Quality control of protein reagents for the improvement of research data reproducibility," Nature Communications, Nature, vol. 12(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23167-z
    DOI: 10.1038/s41467-021-23167-z
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    Cited by:

    1. Philipp K. Zuber & Nelly Said & Tarek Hilal & Bing Wang & Bernhard Loll & Jorge González-Higueras & César A. Ramírez-Sarmiento & Georgiy A. Belogurov & Irina Artsimovitch & Markus C. Wahl & Stefan H., 2024. "Concerted transformation of a hyper-paused transcription complex and its reinforcing protein," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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