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Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries

Author

Listed:
  • Guy Berbers

    (National Institute of Public Health and the Environment)

  • Pieter Gageldonk

    (National Institute of Public Health and the Environment)

  • Jan van de Kassteele

    (National Institute of Public Health and the Environment)

  • Ursula Wiedermann

    (Medical University of Vienna)

  • Isabelle Desombere

    (Sciensano, Public Health Belgium)

  • Tine Dalby

    (Statens Serum Institut)

  • Julie Toubiana

    (Institut Pasteur)

  • Sotirios Tsiodras

    (Hellenic Center for Disease Control)

  • Ildikó Paluska Ferencz

    (National Center for Epidemiology)

  • Kathryn Mullan

    (National Virus reference laboratory)

  • Algirdas Griskevicius

    (National Public Health Surveillance Laboratory)

  • Tatjana Kolupajeva

    (Molecular Biology Department, NRL)

  • Didrik Frimann Vestrheim

    (Norwegian Institute of Public Health)

  • Paula Palminha

    (National Institute of Health)

  • Odette Popovici

    (National Institute of Public Health)

  • Lena Wehlin

    (Public Health Agency of Sweden)

  • Tamara Kastrin

    (Slovenia National Laboratory of Health, Environment and Food)

  • Lucia Maďarová

    (Regional Authority of Public Health)

  • Helen Campbell

    (Public Health England)

  • Csaba Ködmön

    (European Center for Disease Prevention and Control)

  • Sabrina Bacci

    (European Center for Disease Prevention and Control)

  • Alex-Mikael Barkoff

    (University of Turku)

  • Qiushui He

    (University of Turku
    Capital Medical University)

Abstract

Reported incidence of pertussis in the European Union (EU) and the European Economic Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection against diphtheria and tetanus seems sufficient. We aimed to determine the seroprevalence of DTP antibodies in EU/EEA countries within the age groups of 40–49 and 50–59 years. Eighteen countries collected around 500 samples between 2015 and 2018 (N = 10,302) which were analysed for IgG-DTP specific antibodies. The proportion of sera with pertussis toxin antibody levels ≥100 IU/mL, indicative of recent exposure to pertussis was comparable for 13/18 countries, ranging between 2.7–5.8%. For diphtheria the proportion of sera lacking the protective level (

Suggested Citation

  • Guy Berbers & Pieter Gageldonk & Jan van de Kassteele & Ursula Wiedermann & Isabelle Desombere & Tine Dalby & Julie Toubiana & Sotirios Tsiodras & Ildikó Paluska Ferencz & Kathryn Mullan & Algirdas Gr, 2021. "Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23114-y
    DOI: 10.1038/s41467-021-23114-y
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