IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-23049-4.html
   My bibliography  Save this article

The effect of generic market entry on antibiotic prescriptions in the United States

Author

Listed:
  • Cecilia Kållberg

    (University of Oslo
    Norwegian Institute of Public Health)

  • Jemma Hudson

    (University of Aberdeen)

  • Hege Salvesen Blix

    (Norwegian Institute of Public Health
    University of Oslo)

  • Christine Årdal

    (Norwegian Institute of Public Health)

  • Eili Klein

    (Center for Disease Dynamics, Economics and Policy
    Johns Hopkins School of Medicine
    Johns Hopkins Bloomberg School of Public Health)

  • Morten Lindbæk

    (University of Oslo)

  • Kevin Outterson

    (Boston University
    CARB-X)

  • John-Arne Røttingen

    (University of Oslo
    Norwegian Institute of Public Health
    The Research Council of Norway)

  • Ramanan Laxminarayan

    (Center for Disease Dynamics, Economics and Policy
    Princeton University)

Abstract

When patented, brand-name antibiotics lose market exclusivity, generics typically enter the market at lower prices, which may increase consumption of the drug. To examine the effect of generic market entry on antibiotic consumption in the United States, we conducted an interrupted time series analysis of the change in the number of prescriptions per month for antibiotics for which at least one generic entered the US market between 2000 and 2012. Data were acquired from the IQVIA Xponent database. Thirteen antibiotics were analyzed. Here, we show that one year after generic entry, the number of prescriptions increased for five antibiotics (5 to 406%)—aztreonam, cefpodoxime, ciprofloxacin, levofloxacin, ofloxacin—and decreased for one drug: cefdinir. These changes were sustained two years after. Cefprozil, cefuroxime axetil and clarithromycin had significant increases in trend, but no significant level changes. No consistent pattern for antibiotic use following generic entry in the United States was observed.

Suggested Citation

  • Cecilia Kållberg & Jemma Hudson & Hege Salvesen Blix & Christine Årdal & Eili Klein & Morten Lindbæk & Kevin Outterson & John-Arne Røttingen & Ramanan Laxminarayan, 2021. "The effect of generic market entry on antibiotic prescriptions in the United States," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23049-4
    DOI: 10.1038/s41467-021-23049-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-23049-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-23049-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23049-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.