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Gut microbiome modulates Drosophila aggression through octopamine signaling

Author

Listed:
  • Yicong Jia

    (Hubei University
    Shanxi Medical University)

  • Shan Jin

    (Hubei University)

  • Kunkun Hu

    (Hubei University
    Shanxi Medical University)

  • Lei Geng

    (Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Caihong Han

    (Southeast University)

  • Ruxue Kang

    (Shanxi Medical University)

  • Yuxin Pang

    (Shanxi Medical University)

  • Erjun Ling

    (Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)

  • Eng King Tan

    (Department of Neurology, National Neuroscience Institute, Singapore General Hospital Campus)

  • Yufeng Pan

    (Southeast University
    Nantong University)

  • Wei Liu

    (Hubei University
    Shanxi Medical University
    Southeast University
    Department of Neurology, National Neuroscience Institute, Singapore General Hospital Campus)

Abstract

Gut microbiome profoundly affects many aspects of host physiology and behaviors. Here we report that gut microbiome modulates aggressive behaviors in Drosophila. We found that germ-free males showed substantial decrease in inter-male aggression, which could be rescued by microbial re-colonization. These germ-free males are not as competitive as wild-type males for mating with females, although they displayed regular levels of locomotor and courtship behaviors. We further found that Drosophila microbiome interacted with diet during a critical developmental period for the proper expression of octopamine and manifestation of aggression in adult males. These findings provide insights into how gut microbiome modulates specific host behaviors through interaction with diet during development.

Suggested Citation

  • Yicong Jia & Shan Jin & Kunkun Hu & Lei Geng & Caihong Han & Ruxue Kang & Yuxin Pang & Erjun Ling & Eng King Tan & Yufeng Pan & Wei Liu, 2021. "Gut microbiome modulates Drosophila aggression through octopamine signaling," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23041-y
    DOI: 10.1038/s41467-021-23041-y
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    Cited by:

    1. Martina Montanari & Gérard Manière & Martine Berthelot-Grosjean & Yves Dusabyinema & Benjamin Gillet & Yaël Grosjean & C. Léopold Kurz & Julien Royet, 2024. "Larval microbiota primes the Drosophila adult gustatory response," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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