IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-23034-x.html
   My bibliography  Save this article

A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

Author

Listed:
  • Louciné Mitoyan

    (CRCM, Epithelial Stem Cells and Cancer Team)

  • Véronique Chevrier

    (CRCM, Epithelial Stem Cells and Cancer Team)

  • Hector Hernandez-Vargas

    (Université de Lyon, Centre Léon Bérard
    Centre Léon Bérard)

  • Alexane Ollivier

    (CRCM, Epithelial Stem Cells and Cancer Team)

  • Zeinab Homayed

    (Institut de Génomique Fonctionnelle)

  • Julie Pannequin

    (Institut de Génomique Fonctionnelle)

  • Flora Poizat

    (Institut Paoli-Calmettes)

  • Cécile Biasi-Cador

    (Institut Paoli-Calmettes)

  • Emmanuelle Charafe-Jauffret

    (CRCM, Epithelial Stem Cells and Cancer Team
    Institut Paoli-Calmettes)

  • Christophe Ginestier

    (CRCM, Epithelial Stem Cells and Cancer Team)

  • Géraldine Guasch

    (CRCM, Epithelial Stem Cells and Cancer Team)

Abstract

At numerous locations of the body, transition zones are localized at the crossroad between two types of epithelium and are frequently associated with neoplasia involving both type of tissues. These transition zones contain cells expressing markers of adult stem cells that can be the target of early transformation. The mere fact that transition zone cells can merge different architecture with separate functions implies for a unique plasticity that these cells must display in steady state. However, their roles during tissue regeneration in normal and injured state remain unknown. Here, by using in vivo lineage tracing, single-cell transcriptomics, computational modeling and a three-dimensional organoid culture system of transition zone cells, we identify a population of Krt17+ basal cells with multipotent properties at the squamo-columnar anorectal junction that maintain a squamous epithelium during normal homeostasis and can participate in the repair of a glandular epithelium following tissue injury.

Suggested Citation

  • Louciné Mitoyan & Véronique Chevrier & Hector Hernandez-Vargas & Alexane Ollivier & Zeinab Homayed & Julie Pannequin & Flora Poizat & Cécile Biasi-Cador & Emmanuelle Charafe-Jauffret & Christophe Gine, 2021. "A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23034-x
    DOI: 10.1038/s41467-021-23034-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-23034-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-23034-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-23034-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.