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Taxonomic signatures of cause-specific mortality risk in human gut microbiome

Author

Listed:
  • Aaro Salosensaari

    (Turku University Hospital and University of Turku
    University of Turku
    University of Turku)

  • Ville Laitinen

    (University of Turku)

  • Aki S. Havulinna

    (Finnish Institute for Health and Welfare
    FIMM-HiLIFE)

  • Guillaume Meric

    (Baker Heart and Diabetes Institute
    University of Cambridge)

  • Susan Cheng

    (Brigham and Women’s Hospital
    Cedars-Sinai Medical Center)

  • Markus Perola

    (Finnish Institute for Health and Welfare)

  • Liisa Valsta

    (Finnish Institute for Health and Welfare)

  • Georg Alfthan

    (Finnish Institute for Health and Welfare)

  • Michael Inouye

    (Baker Heart and Diabetes Institute
    University of Cambridge)

  • Jeramie D. Watrous

    (University of California San Diego)

  • Tao Long

    (University of California San Diego)

  • Rodolfo A. Salido

    (University of California San Diego)

  • Karenina Sanders

    (University of California San Diego)

  • Caitriona Brennan

    (University of California San Diego)

  • Gregory C. Humphrey

    (University of California San Diego)

  • Jon G. Sanders

    (University of California San Diego)

  • Mohit Jain

    (University of California San Diego)

  • Pekka Jousilahti

    (Finnish Institute for Health and Welfare)

  • Veikko Salomaa

    (Finnish Institute for Health and Welfare)

  • Rob Knight

    (University of California San Diego)

  • Leo Lahti

    (University of Turku)

  • Teemu Niiranen

    (Turku University Hospital and University of Turku
    Finnish Institute for Health and Welfare)

Abstract

The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status.

Suggested Citation

  • Aaro Salosensaari & Ville Laitinen & Aki S. Havulinna & Guillaume Meric & Susan Cheng & Markus Perola & Liisa Valsta & Georg Alfthan & Michael Inouye & Jeramie D. Watrous & Tao Long & Rodolfo A. Salid, 2021. "Taxonomic signatures of cause-specific mortality risk in human gut microbiome," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22962-y
    DOI: 10.1038/s41467-021-22962-y
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