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Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice

Author

Listed:
  • Can Liu

    (Tsinghua University
    National Institute of Biological Sciences (NIBS))

  • Chia-Ying Lee

    (University of Tsukuba)

  • Greg Asher

    (University of Tsukuba)

  • Liqin Cao

    (University of Tsukuba)

  • Yuka Terakoshi

    (University of Tsukuba)

  • Peng Cao

    (National Institute of Biological Sciences (NIBS)
    Tsinghua University)

  • Reiko Kobayakawa

    (Kansai Medical University)

  • Ko Kobayakawa

    (Kansai Medical University)

  • Katsuyasu Sakurai

    (University of Tsukuba)

  • Qinghua Liu

    (National Institute of Biological Sciences (NIBS)
    University of Tsukuba
    Tsinghua University)

Abstract

The neural mechanisms of fear-associated thermoregulation remain unclear. Innate fear odor 2-methyl-2-thiazoline (2MT) elicits rapid hypothermia and elevated tail temperature, indicative of vasodilation-induced heat dissipation, in wild-type mice, but not in mice lacking Trpa1–the chemosensor for 2MT. Here we report that Trpa1−/− mice show diminished 2MT-evoked c-fos expression in the posterior subthalamic nucleus (PSTh), external lateral parabrachial subnucleus (PBel) and nucleus of the solitary tract (NTS). Whereas tetanus toxin light chain-mediated inactivation of NTS-projecting PSTh neurons suppress, optogenetic activation of direct PSTh-rostral NTS pathway induces hypothermia and tail vasodilation. Furthermore, selective opto-stimulation of 2MT-activated, PSTh-projecting PBel neurons by capturing activated neuronal ensembles (CANE) causes hypothermia. Conversely, chemogenetic suppression of vGlut2+ neurons in PBel or PSTh, or PSTh-projecting PBel neurons attenuates 2MT-evoked hypothermia and tail vasodilation. These studies identify PSTh as a major thermoregulatory hub that connects PBel to NTS to mediate 2MT-evoked innate fear-associated hypothermia and tail vasodilation.

Suggested Citation

  • Can Liu & Chia-Ying Lee & Greg Asher & Liqin Cao & Yuka Terakoshi & Peng Cao & Reiko Kobayakawa & Ko Kobayakawa & Katsuyasu Sakurai & Qinghua Liu, 2021. "Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22914-6
    DOI: 10.1038/s41467-021-22914-6
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    Cited by:

    1. Wen Z. Yang & Hengchang Xie & Xiaosa Du & Qian Zhou & Yan Xiao & Zhengdong Zhao & Xiaoning Jia & Jianhui Xu & Wen Zhang & Shuang Cai & Zhangjie Li & Xin Fu & Rong Hua & Junhao Cai & Shuang Chang & Jin, 2023. "A parabrachial-hypothalamic parallel circuit governs cold defense in mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Han Guo & Jian-Bo Jiang & Wei Xu & Mu-Tian Zhang & Hui Chen & Huan-Ying Shi & Lu Wang & Miao He & Michael Lazarus & Shan-Qun Li & Zhi-Li Huang & Wei-Min Qu, 2023. "Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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