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Sex differences in fear memory consolidation via Tac2 signaling in mice

Author

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  • A. Florido

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona)

  • E. R. Velasco

    (Universitat Autònoma de Barcelona)

  • C. M. Soto-Faguás

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona
    Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III)

  • A. Gomez-Gomez

    (Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute))

  • L. Perez-Caballero

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona)

  • P. Molina

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona)

  • R. Nadal

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona
    Centro de Investigación Biomédica En Red en Salud Mental (CIBERSAM), Instituto de Salud Carlos III
    Universitat Autònoma de Barcelona)

  • O. J. Pozo

    (Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute))

  • C. A. Saura

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona
    Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III)

  • R. Andero

    (Universitat Autònoma de Barcelona
    Universitat Autònoma de Barcelona
    Centro de Investigación Biomédica En Red en Salud Mental (CIBERSAM), Instituto de Salud Carlos III
    Universitat Autònoma de Barcelona)

Abstract

Memory formation is key for brain functioning. Uncovering the memory mechanisms is helping us to better understand neural processes in health and disease. Moreover, more specific treatments for fear-related disorders such as posttraumatic stress disorder and phobias may help to decrease their negative impact on mental health. In this line, the Tachykinin 2 (Tac2) pathway in the central amygdala (CeA) has been shown to be sufficient and necessary for the modulation of fear memory consolidation. CeA-Tac2 antagonism and its pharmacogenetic temporal inhibition impair fear memory in male mice. Surprisingly, we demonstrate here the opposite effect of Tac2 blockade on enhancing fear memory consolidation in females. Furthermore, we show that CeA-testosterone in males, CeA-estradiol in females and Akt/GSK3β/β-Catenin signaling both mediate the opposite-sex differential Tac2 pathway regulation of fear memory.

Suggested Citation

  • A. Florido & E. R. Velasco & C. M. Soto-Faguás & A. Gomez-Gomez & L. Perez-Caballero & P. Molina & R. Nadal & O. J. Pozo & C. A. Saura & R. Andero, 2021. "Sex differences in fear memory consolidation via Tac2 signaling in mice," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22911-9
    DOI: 10.1038/s41467-021-22911-9
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    Cited by:

    1. Alicia Hernández-Vivanco & Nuria Cano-Adamuz & Alberto Sánchez-Aguilera & Alba González-Alonso & Alberto Rodríguez-Fernández & Íñigo Azcoitia & Liset Menendez de la Prida & Pablo Méndez, 2022. "Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Masato Tsuji & Yuto Nishizuka & Kazuo Emoto, 2023. "Threat gates visual aversion via theta activity in Tachykinergic neurons," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Blake J. Laham & Sahana S. Murthy & Monica Hanani & Mona Clappier & Sydney Boyer & Betsy Vasquez & Elizabeth Gould, 2022. "The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. E. R. Velasco & A. Florido & Á Flores & E. Senabre & A. Gomez-Gomez & A. Torres & A. Roca & S. Norrholm & E. L. Newman & P. Das & R. A. Ross & A. Lori & O. J. Pozo & K. J. Ressler & L. L. Garcia-Estev, 2022. "PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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