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Bidirectional propagation of low frequency oscillations over the human hippocampal surface

Author

Listed:
  • Jonathan K. Kleen

    (University of California San Francisco)

  • Jason E. Chung

    (University of California San Francisco)

  • Kristin K. Sellers

    (University of California San Francisco)

  • Jenny Zhou

    (Lawrence Livermore National Laboratories)

  • Michael Triplett

    (Lawrence Livermore National Laboratories)

  • Kye Lee

    (Lawrence Livermore National Laboratories)

  • Angela Tooker

    (Lawrence Livermore National Laboratories)

  • Razi Haque

    (Lawrence Livermore National Laboratories)

  • Edward F. Chang

    (University of California San Francisco)

Abstract

The hippocampus is diversely interconnected with other brain systems along its axis. Cycles of theta-frequency activity are believed to propagate from the septal to temporal pole, yet it is unclear how this one-way route supports the flexible cognitive capacities of this structure. We leveraged novel thin-film microgrid arrays conformed to the human hippocampal surface to track neural activity two-dimensionally in vivo. All oscillation frequencies identified between 1–15 Hz propagated across the tissue. Moreover, they dynamically shifted between two roughly opposite directions oblique to the long axis. This predominant propagation axis was mirrored across participants, hemispheres, and consciousness states. Directionality was modulated in a participant who performed a behavioral task, and it could be predicted by wave amplitude topography over the hippocampal surface. Our results show that propagation directions may thus represent distinct meso-scale network computations, operating along versatile spatiotemporal processing routes across the hippocampal body.

Suggested Citation

  • Jonathan K. Kleen & Jason E. Chung & Kristin K. Sellers & Jenny Zhou & Michael Triplett & Kye Lee & Angela Tooker & Razi Haque & Edward F. Chang, 2021. "Bidirectional propagation of low frequency oscillations over the human hippocampal surface," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22850-5
    DOI: 10.1038/s41467-021-22850-5
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    Cited by:

    1. Erfan Zabeh & Nicholas C. Foley & Joshua Jacobs & Jacqueline P. Gottlieb, 2023. "Beta traveling waves in monkey frontal and parietal areas encode recent reward history," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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