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Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

Author

Listed:
  • Edward A. Hayter

    (University of Manchester)

  • Sophie M. T. Wehrens

    (University of Surrey)

  • Hans P. A. Dongen

    (Washington State University
    Washington State University)

  • Alessandra Stangherlin

    (MRC Laboratory of Molecular Biology)

  • Shobhan Gaddameedhi

    (North Carolina State University)

  • Elena Crooks

    (Washington State University
    Eastern Washington University)

  • Nichola J. Barron

    (University of Manchester)

  • Luigi A. Venetucci

    (University of Manchester)

  • John S. O’Neill

    (MRC Laboratory of Molecular Biology)

  • Timothy M. Brown

    (University of Manchester)

  • Debra J. Skene

    (University of Surrey)

  • Andrew W. Trafford

    (University of Manchester
    University of Manchester)

  • David A. Bechtold

    (University of Manchester)

Abstract

Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial (SA) and atrioventricular (AV) node activity, and impose a time-of–day dependent susceptibility to ventricular arrhythmia. Critically, the balance of circadian inputs from the autonomic nervous system and cardiomyocyte clock to the SA and AV nodes differ, and this renders the cardiac conduction system sensitive to decoupling during abrupt shifts in behavioural routine and sleep-wake timing. Our findings reveal a functional segregation of circadian control across the heart’s conduction system and inherent susceptibility to arrhythmia.

Suggested Citation

  • Edward A. Hayter & Sophie M. T. Wehrens & Hans P. A. Dongen & Alessandra Stangherlin & Shobhan Gaddameedhi & Elena Crooks & Nichola J. Barron & Luigi A. Venetucci & John S. O’Neill & Timothy M. Brown , 2021. "Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22788-8
    DOI: 10.1038/s41467-021-22788-8
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    Cited by:

    1. Alessandra Stangherlin & Joseph L. Watson & David C. S. Wong & Silvia Barbiero & Aiwei Zeng & Estere Seinkmane & Sew Peak Chew & Andrew D. Beale & Edward A. Hayter & Alina Guna & Alison J. Inglis & Ma, 2021. "Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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