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Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii

Author

Listed:
  • Tao Luo

    (Sichuan University
    Fudan University)

  • Peng Xu

    (Fudan University
    Zunyi Medical University)

  • Yangyi Zhang

    (Shanghai Municipal Centre for Disease Control and Prevention)

  • Jessica L. Porter

    (University of Melbourne
    University of Melbourne)

  • Marwan Ghanem

    (McGill University and McGill International TB Centre)

  • Qingyun Liu

    (Fudan University)

  • Yuan Jiang

    (Shanghai Municipal Centre for Disease Control and Prevention)

  • Jing Li

    (Shanghai Municipal Centre for Disease Control and Prevention)

  • Qing Miao

    (Fudan University)

  • Bijie Hu

    (Fudan University)

  • Benjamin P. Howden

    (University of Melbourne
    University of Melbourne
    University of Melbourne)

  • Janet A. M. Fyfe

    (Melbourne Health)

  • Maria Globan

    (Melbourne Health)

  • Wencong He

    (Chinese Center for Disease Control and Prevention and Beijing Tuberculosis and Thoracic Tumor Research Institute)

  • Ping He

    (Chinese Center for Disease Control and Prevention and Beijing Tuberculosis and Thoracic Tumor Research Institute)

  • Yiting Wang

    (Chinese Center for Disease Control and Prevention and Beijing Tuberculosis and Thoracic Tumor Research Institute)

  • Houming Liu

    (Southern University of Science and Technology)

  • Howard E. Takiff

    (Institut Pasteur
    IVIC
    Shenzhen Nanshan Center for Chronic Disease Control)

  • Yanlin Zhao

    (Chinese Center for Disease Control and Prevention and Beijing Tuberculosis and Thoracic Tumor Research Institute)

  • Xinchun Chen

    (Shenzhen University School of Medicine)

  • Qichao Pan

    (Shanghai Municipal Centre for Disease Control and Prevention)

  • Marcel A. Behr

    (McGill University and McGill International TB Centre)

  • Timothy P. Stinear

    (University of Melbourne
    University of Melbourne)

  • Qian Gao

    (Fudan University)

Abstract

Mycobacterium kansasii can cause serious pulmonary disease. It belongs to a group of closely-related species of non-tuberculous mycobacteria known as the M. kansasii complex (MKC). Here, we report a population genomics analysis of 358 MKC isolates from worldwide water and clinical sources. We find that recombination, likely mediated by distributive conjugative transfer, has contributed to speciation and on-going diversification of the MKC. Our analyses support municipal water as a main source of MKC infections. Furthermore, nearly 80% of the MKC infections are due to closely-related M. kansasii strains, forming a main cluster that apparently originated in the 1900s and subsequently expanded globally. Bioinformatic analyses indicate that several genes involved in metabolism (e.g., maintenance of the methylcitrate cycle), ESX-I secretion, metal ion homeostasis and cell surface remodelling may have contributed to M. kansasii’s success and its ongoing adaptation to the human host.

Suggested Citation

  • Tao Luo & Peng Xu & Yangyi Zhang & Jessica L. Porter & Marwan Ghanem & Qingyun Liu & Yuan Jiang & Jing Li & Qing Miao & Bijie Hu & Benjamin P. Howden & Janet A. M. Fyfe & Maria Globan & Wencong He & P, 2021. "Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22760-6
    DOI: 10.1038/s41467-021-22760-6
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    Cited by:

    1. Christopher Ruis & Aaron Weimann & Gerry Tonkin-Hill & Arun Prasad Pandurangan & Marta Matuszewska & Gemma G. R. Murray & Roger C. Lévesque & Tom L. Blundell & R. Andres Floto & Julian Parkhill, 2023. "Mutational spectra are associated with bacterial niche," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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