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Emerging concepts in intestinal immune control of obesity-related metabolic disease

Author

Listed:
  • Saad Khan

    (University of Toronto
    University Health Network)

  • Helen Luck

    (University Health Network)

  • Shawn Winer

    (University of Toronto
    St. Michael’s Hospital)

  • Daniel A. Winer

    (University of Toronto
    University Health Network
    University of Toronto
    University Health Network)

Abstract

The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestinal permeability, immune cell trafficking, and intestinal hormone availability, impacting systemic insulin resistance. Understanding these pathways might identify mechanisms underlying treatments for insulin resistance, such as metformin and bariatric surgery, or aid in developing new therapies and vaccination approaches. Here, we highlight evolving concepts centered on intestinal immunity, diet, and the microbiota to provide a working model of obesity-related metabolic disease.

Suggested Citation

  • Saad Khan & Helen Luck & Shawn Winer & Daniel A. Winer, 2021. "Emerging concepts in intestinal immune control of obesity-related metabolic disease," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22727-7
    DOI: 10.1038/s41467-021-22727-7
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