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The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation

Author

Listed:
  • Richard J. Acton

    (Queen Mary University of London
    University of Southampton
    University of Southampton)

  • Wei Yuan

    (King’s College London
    Institute of Cancer Research)

  • Fei Gao

    (BGI-Shenzhen)

  • Yudong Xia

    (BGI-Shenzhen)

  • Emma Bourne

    (Queen Mary University of London)

  • Eva Wozniak

    (Queen Mary University of London)

  • Jordana Bell

    (King’s College London)

  • Karen Lillycrop

    (University of Southampton)

  • Jun Wang

    (Shenzhen Digital Life Institute
    iCarbonX
    Macau University of Science and Technology)

  • Elaine Dennison

    (University of Southampton)

  • Nicholas C. Harvey

    (University of Southampton)

  • Charles A. Mein

    (Queen Mary University of London)

  • Tim D. Spector

    (King’s College London)

  • Pirro G. Hysi

    (King’s College London)

  • Cyrus Cooper

    (University of Southampton)

  • Christopher G. Bell

    (Queen Mary University of London)

Abstract

The epigenome has been shown to deteriorate with age, potentially impacting on ageing-related disease. tRNA, while arising from only ˜46 kb (

Suggested Citation

  • Richard J. Acton & Wei Yuan & Fei Gao & Yudong Xia & Emma Bourne & Eva Wozniak & Jordana Bell & Karen Lillycrop & Jun Wang & Elaine Dennison & Nicholas C. Harvey & Charles A. Mein & Tim D. Spector & P, 2021. "The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22639-6
    DOI: 10.1038/s41467-021-22639-6
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    Cited by:

    1. Yudong Fu & Fan Jiang & Xiao Zhang & Yingyi Pan & Rui Xu & Xiu Liang & Xiaofen Wu & Xingqiang Li & Kaixuan Lin & Ruona Shi & Xiaofei Zhang & Dominique Ferrandon & Jing Liu & Duanqing Pei & Jie Wang & , 2024. "Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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