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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Author

Listed:
  • Itziar Rojas

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Sonia Moreno-Grau

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Niccolo Tesi

    (Vrije Universiteit Amsterdam, Amsterdam UMC
    Vrije Universiteit Amsterdam, Amsterdam UMC
    Delft Univeristy of Technology)

  • Benjamin Grenier-Boley

    (U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases)

  • Victor Andrade

    (Medical Faculty
    University Clinic Bonn)

  • Iris E. Jansen

    (Vrije Universiteit Amsterdam, Amsterdam UMC
    VU University)

  • Nancy L. Pedersen

    (Karolinska Institutet)

  • Najada Stringa

    (Amsterdam Public Health Research Institute)

  • Anna Zettergren

    (University of Gothenburg)

  • Isabel Hernández

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Laura Montrreal

    (Universitat Internacional de Catalunya)

  • Carmen Antúnez

    (Hospital Clínico Universitario Virgen de la Arrixaca)

  • Anna Antonell

    (University of Barcelona)

  • Rick M. Tankard

    (Murdoch University)

  • Joshua C. Bis

    (University of Washington)

  • Rebecca Sims

    (Cardiff University)

  • Céline Bellenguez

    (U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases)

  • Inés Quintela

    (Universidade de Santiago de Compostela)

  • Antonio González-Perez

    (CAEBI, Centro Andaluz de Estudios Bioinformáticos)

  • Miguel Calero

    (National Institute of Health Carlos III
    UFIEC, Instituto de Salud Carlos III
    CIEN Foundation/Queen Sofia Foundation Alzheimer Center)

  • Emilio Franco-Macías

    (Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla)

  • Juan Macías

    (Hospital Universitario de Valme)

  • Rafael Blesa

    (National Institute of Health Carlos III
    Universitat Autònoma de Barcelona)

  • Laura Cervera-Carles

    (National Institute of Health Carlos III
    Universitat Autònoma de Barcelona)

  • Manuel Menéndez-González

    (Hospital Universitario Central de Asturias
    Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
    Universidad de Oviedo)

  • Ana Frank-García

    (National Institute of Health Carlos III
    Instituto de Investigación Sanitaria del Hospital Universitario La Paz, IdiPAZ
    Hospital La Paz Institute for Health Research, IdiPAZ
    Universidad Autónoma de Madrid)

  • Jose Luís Royo

    (University of Málaga)

  • Fermin Moreno

    (National Institute of Health Carlos III
    Hospital Universitario Donostia
    Instituto Biodonostia)

  • Raquel Huerto Vilas

    (Hospital Universitari Santa Maria de Lleida
    Institut de Recerca Biomedica de Lleida (IRBLLeida))

  • Miquel Baquero

    (Hospital Universitari i Politècnic La Fe)

  • Mónica Diez-Fairen

    (Fundació Docència i Recerca MútuaTerrassa, Terrassa
    Hospital Universitari Mutua de Terrassa, Terrassa)

  • Carmen Lage

    (National Institute of Health Carlos III
    Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL))

  • Sebastián García-Madrona

    (Hospital Universitario Ramon y Cajal, IRYCIS)

  • Pablo García-González

    (Universitat Internacional de Catalunya)

  • Emilio Alarcón-Martín

    (Universitat Internacional de Catalunya
    University of Málaga)

  • Sergi Valero

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Oscar Sotolongo-Grau

    (Universitat Internacional de Catalunya)

  • Abbe Ullgren

    (Division of Neurogeriatrics
    Karolinska University Hospital-Solna)

  • Adam C. Naj

    (University of Pennsylvania Perelman School of Medicine
    University of Pennsylvania Perelman School of Medicine)

  • Afina W. Lemstra

    (Vrije Universiteit Amsterdam, Amsterdam UMC)

  • Alba Benaque

    (Universitat Internacional de Catalunya)

  • Alba Pérez-Cordón

    (Universitat Internacional de Catalunya)

  • Alberto Benussi

    (University of Brescia)

  • Alberto Rábano

    (National Institute of Health Carlos III
    CIEN Foundation/Queen Sofia Foundation Alzheimer Center
    BT-CIEN)

  • Alessandro Padovani

    (University of Brescia)

  • Alessio Squassina

    (University of Cagliari)

  • Alexandre de Mendonça

    (University of Lisbon)

  • Alfonso Arias Pastor

    (Hospital Universitari Santa Maria de Lleida
    Institut de Recerca Biomedica de Lleida (IRBLLeida))

  • Almar A. L. Kok

    (Amsterdam Public Health Research Institute
    Amsterdam Public Health Research Institute)

  • Alun Meggy

    (Cardiff University)

  • Ana Belén Pastor

    (CIEN Foundation/Queen Sofia Foundation Alzheimer Center
    BT-CIEN)

  • Ana Espinosa

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Anaïs Corma-Gómez

    (Hospital Universitario de Valme)

  • Angel Martín Montes

    (National Institute of Health Carlos III
    Hospital La Paz Institute for Health Research, IdiPAZ
    La Paz University Hospital)

  • Ángela Sanabria

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Anita L. DeStefano

    (Boston University School of Medicine
    Boston University School of Public Health)

  • Anja Schneider

    (University Clinic Bonn
    German Center for Neurodegenerative Diseases (DZNE))

  • Annakaisa Haapasalo

    (University of Eastern Finland)

  • Anne Kinhult Ståhlbom

    (Division of Neurogeriatrics
    Karolinska University Hospital-Solna)

  • Anne Tybjærg-Hansen

    (Rigshospitalet
    University of Copenhagen)

  • Annette M. Hartmann

    (University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics)

  • Annika Spottke

    (German Center for Neurodegenerative Diseases (DZNE)
    University of Bonn)

  • Arturo Corbatón-Anchuelo

    (Hospital Clínico San Carlos (IdISSC)
    Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM))

  • Arvid Rongve

    (Helse Fonna, Department of Research and Innovation
    University of Bergen, Institute of Clinical Medicine (K1))

  • Barbara Borroni

    (University of Brescia)

  • Beatrice Arosio

    (University of Milan
    IRCCS Ospedale Maggiore Policlinico)

  • Benedetta Nacmias

    (Drug Research and Child Health University of Florence
    IRCCS Fondazione Don Carlo Gnocchi)

  • Børge G. Nordestgaard

    (University of Copenhagen
    Herlev Gentofte Hospital)

  • Brian W. Kunkle

    (University of Miami Miller School of Medicine
    University of Miami Miller School of Medicine)

  • Camille Charbonnier

    (FHU G4 Génomique)

  • Carla Abdelnour

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Carlo Masullo

    (School of Medicine)

  • Carmen Martínez Rodríguez

    (Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
    Hospital de Cabueñes)

  • Carmen Muñoz-Fernandez

    (Hospital Universitario de Gran Canaria Dr.Negrín)

  • Carole Dufouil

    (Univ Bordeaux
    CHU de Bordeaux, Pole de Santé Publique)

  • Caroline Graff

    (Division of Neurogeriatrics
    Karolinska University Hospital-Solna)

  • Catarina B. Ferreira

    (Universidade de Lisboa)

  • Caterina Chillotti

    (University Hospital of Cagliari)

  • Chandra A. Reynolds

    (University of California—Riverside)

  • Chiara Fenoglio

    (Dino Ferrari Center)

  • Christine Van Broeckhoven

    (VIB Center for Molecular Neurology
    Institute Born-Bunge
    University of Antwerp.)

  • Christopher Clark

    (University of Zürich)

  • Claudia Pisanu

    (University of Cagliari)

  • Claudia L. Satizabal

    (Boston University School of Medicine
    Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases
    UT Health San Antonio)

  • Clive Holmes

    (University of Southampton)

  • Dolores Buiza-Rueda

    (National Institute of Health Carlos III
    Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla)

  • Dag Aarsland

    (King’s College London
    Stavanger University Hospital)

  • Dan Rujescu

    (University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics)

  • Daniel Alcolea

    (National Institute of Health Carlos III
    Universitat Autònoma de Barcelona)

  • Daniela Galimberti

    (Dino Ferrari Center
    Fondazione IRCCS Ca’ Granda, Ospedale Policlinico)

  • David Wallon

    (Normandie Univ, UNIROUEN, Inserm U1245, CHU Rouen, Department of Neurology and CNR-MAJ, FHU G4 Génomique)

  • Davide Seripa

    (Complex Structure of Geriatrics, Department of Medical Sciences Fondazione IRCCS Casa Sollievo della Sofferenza)

  • Edna Grünblatt

    (University of Zurich
    University of Zurich and ETH Zurich
    University of Zurich)

  • Efthimios Dardiotis

    (University of Thessaly)

  • Emrah Düzel

    (German Center for Neurodegenerative Diseases (DZNE)
    Otto-von-Guericke University)

  • Elio Scarpini

    (Dino Ferrari Center
    Fondazione IRCCS Ca’ Granda, Ospedale Policlinico)

  • Elisa Conti

    (University of Milano-Bicocca and Milan Center for Neuroscience)

  • Elisa Rubino

    (AOU Città della Salute e della Scienza di Torino)

  • Ellen Gelpi

    (Institut d’Investigacions Biomèdiques August Pi i Sunyer
    Medical University of Vienna)

  • Eloy Rodriguez-Rodriguez

    (National Institute of Health Carlos III
    Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL))

  • Emmanuelle Duron

    (APHP, Hôpital Brousse, equipe INSERM 1178, MOODS
    Le Kremlin-Bicêtre
    APHP, Hôpital Broca)

  • Eric Boerwinkle

    (University of Texas Health Science Center at Houston
    Baylor College of Medicine)

  • Evelyn Ferri

    (IRCCS Ospedale Maggiore Policlinico)

  • Fabrizio Tagliavini

    (Fondazione IRCCS Istituto Neurologico Carlo Besta)

  • Fahri Küçükali

    (VIB Center for Molecular Neurology
    Institute Born-Bunge
    University of Antwerp.)

  • Florence Pasquier

    (Univ Lille
    CHU CNR-MAJ)

  • Florentino Sanchez-Garcia

    (Hospital Universitario de Gran Canaria Dr. Negrín)

  • Francesca Mangialasche

    (Karolinska Institutet)

  • Frank Jessen

    (German Center for Neurodegenerative Diseases (DZNE)
    Medical Faculty
    University of Cologne)

  • Gaël Nicolas

    (Hospital de Cabueñes)

  • Geir Selbæk

    (Vestfold Hospital Trust
    Oslo University Hospital
    University of Oslo)

  • Gemma Ortega

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Geneviève Chêne

    (Univ Bordeaux
    CHU de Bordeaux, Pole de Santé Publique)

  • Georgios Hadjigeorgiou

    (University of Cyprus)

  • Giacomina Rossi

    (Fondazione IRCCS Istituto Neurologico Carlo Besta)

  • Gianfranco Spalletta

    (IRCCS Santa Lucia Foundation
    Baylor College of Medicine)

  • Giorgio Giaccone

    (Fondazione IRCCS Istituto Neurologico Carlo Besta)

  • Giulia Grande

    (Karolinska Institutet and Stockholm University)

  • Giuliano Binetti

    (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
    IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli)

  • Goran Papenberg

    (Karolinska Institutet and Stockholm University)

  • Harald Hampel

    (Pitié-Salpêtrière Hospital)

  • Henri Bailly

    (APHP, Hôpital Broca
    Université Paris Descartes)

  • Henrik Zetterberg

    (Sahlgrenska University Hospital
    Sahlgrenska Academy at the University of Gothenburg
    UCL Institute of Neurology
    UK Dementia Research Institute at UCL)

  • Hilkka Soininen

    (University of Eastern Finland
    Kuopio University Hospital)

  • Ida K. Karlsson

    (Karolinska Institutet
    Jönköping University)

  • Ignacio Alvarez

    (Fundació Docència i Recerca MútuaTerrassa, Terrassa
    Hospital Universitari Mutua de Terrassa, Terrassa)

  • Ildebrando Appollonio

    (University of Milano-Bicocca and Milan Center for Neuroscience
    Neurology Unit, ‘San Gerardo’ hospital)

  • Ina Giegling

    (University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics)

  • Ingmar Skoog

    (University of Gothenburg)

  • Ingvild Saltvedt

    (University Hospital of Trondheim
    Norwegian University of Science and Technhology (NTNU))

  • Innocenzo Rainero

    (University of Torino)

  • Irene Rosas Allende

    (Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
    Hospital Universitario Central de Asturias)

  • Jakub Hort

    (Charles University
    St. Anne’s University Hospital Brno)

  • Janine Diehl-Schmid

    (Technical University of Munich)

  • Jasper Van Dongen

    (VIB Center for Molecular Neurology
    Institute Born-Bunge)

  • Jean-Sebastien Vidal

    (APHP, Hôpital Broca
    Université Paris Descartes)

  • Jenni Lehtisalo

    (University of Eastern Finland
    Finnish Institute for Health and Welfare)

  • Jens Wiltfang

    (University Medical Center Goettingen
    German Center for Neurodegenerative Diseases (DZNE)
    University of Aveiro)

  • Jesper Qvist Thomassen

    (Rigshospitalet)

  • Johannes Kornhuber

    (Friedrich-Alexander Universität Erlangen-Nürnberg)

  • Jonathan L. Haines

    (Case Western Reserve University
    Case Western Reserve University)

  • Jonathan Vogelgsang

    (University Medical Center Goettingen
    Harvard Medical School)

  • Juan A. Pineda

    (Hospital Universitario de Valme)

  • Juan Fortea

    (National Institute of Health Carlos III
    Universitat Autònoma de Barcelona)

  • Julius Popp

    (University Hospital of Psychiatry Zürich
    University of Zürich
    University Hospital of Lausanne)

  • Jürgen Deckert

    (University Hospital)

  • Katharina Buerger

    (Ludwig-Maximilians-Universität LMU
    German Center for Neurodegenerative Diseases (DZNE))

  • Kevin Morgan

    (University of Nottingham)

  • Klaus Fließbach

    (University Clinic Bonn)

  • Kristel Sleegers

    (VIB Center for Molecular Neurology
    Institute Born-Bunge
    University of Antwerp.)

  • Laura Molina-Porcel

    (University of Barcelona
    Institut d’Investigacions Biomèdiques August Pi i Sunyer)

  • Lena Kilander

    (Department of Public Health and Caring Sciences/Geriatrics)

  • Leonie Weinhold

    (University Hospital of Bonn)

  • Lindsay A. Farrer

    (Boston University Schools of Medicine and Public Health)

  • Li-San Wang

    (University of Pennsylvania Perelman School of Medicine)

  • Luca Kleineidam

    (Medical Faculty
    University Clinic Bonn)

  • Lucia Farotti

    (University of Perugia)

  • Lucilla Parnetti

    (University of Perugia)

  • Lucio Tremolizzo

    (University of Milano-Bicocca and Milan Center for Neuroscience
    Neurology Unit, ‘San Gerardo’ hospital)

  • Lucrezia Hausner

    (University of Heidelberg)

  • Luisa Benussi

    (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli)

  • Lutz Froelich

    (University of Heidelberg)

  • M. Arfan Ikram

    (Erasmus Medical Center)

  • M. Candida Deniz-Naranjo

    (Hospital Universitario de Gran Canaria Dr. Negrín)

  • Magda Tsolaki

    (1st Department of Neurology Aristotle University of Thessaloniki)

  • Maitée Rosende-Roca

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Malin Löwenmark

    (Department of Public Health and Caring Sciences/Geriatrics)

  • Marc Hulsman

    (Vrije Universiteit Amsterdam, Amsterdam UMC
    Vrije Universiteit Amsterdam, Amsterdam UMC)

  • Marco Spallazzi

    (Azienda Ospedaliero-Universitaria)

  • Margaret A. Pericak-Vance

    (University of Miami Miller School of Medicine)

  • Margaret Esiri

    (Nuffield Department of Clinical Neurosciences)

  • María Bernal Sánchez-Arjona

    (Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla)

  • Maria Carolina Dalmasso

    (Medical Faculty)

  • María Teresa Martínez-Larrad

    (Hospital Clínico San Carlos (IdISSC)
    Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM))

  • Marina Arcaro

    (Fondazione IRCCS Ca’ Granda, Ospedale Policlinico)

  • Markus M. Nöthen

    (School of Medicine & University Hospital Bonn)

  • Marta Fernández-Fuertes

    (Hospital Universitario de Valme)

  • Martin Dichgans

    (Ludwig-Maximilians-Universität LMU
    German Center for Neurodegenerative Diseases (DZNE)
    Munich Cluster for Systems Neurology (SyNergy))

  • Martin Ingelsson

    (Department of Public Health and Caring Sciences/Geriatrics)

  • Martin J. Herrmann

    (University Hospital)

  • Martin Scherer

    (University Medical Centre Hamburg-Eppendorf)

  • Martin Vyhnalek

    (Charles University
    St. Anne’s University Hospital Brno)

  • Mary H. Kosmidis

    (Aristotle University of Thessaloniki)

  • Mary Yannakoulia

    (Harokopio University)

  • Matthias Schmid

    (German Center for Neurodegenerative Diseases (DZNE)
    University Hospital of Bonn)

  • Michael Ewers

    (Ludwig-Maximilians-Universität LMU
    German Center for Neurodegenerative Diseases (DZNE))

  • Michael T. Heneka

    (University Clinic Bonn
    German Center for Neurodegenerative Diseases (DZNE))

  • Michael Wagner

    (University Clinic Bonn
    German Center for Neurodegenerative Diseases (DZNE))

  • Michela Scamosci

    (University of Perugia)

  • Miia Kivipelto

    (Karolinska Institutet
    University of Eastern Finland
    Imperial College London
    Research & Development Unit)

  • Mikko Hiltunen

    (University of Eastern Finland)

  • Miren Zulaica

    (National Institute of Health Carlos III
    Instituto Biodonostia)

  • Montserrat Alegret

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Myriam Fornage

    (University of Texas Health Sciences Center at Houston)

  • Natalia Roberto

    (Universitat Internacional de Catalunya)

  • Natasja M. van Schoor

    (Amsterdam Public Health Research Institute)

  • Nazib M. Seidu

    (University of Gothenburg)

  • Nerisa Banaj

    (IRCCS Santa Lucia Foundation)

  • Nicola J. Armstrong

    (Murdoch University)

  • Nikolaos Scarmeas

    (National and Kapodistrian University of Athens, Medical School
    Columbia University)

  • Norbert Scherbaum

    (University of Duisburg-Essen)

  • Oliver Goldhardt

    (Technical University of Munich)

  • Oliver Hanon

    (APHP, Hôpital Broca
    Université Paris Descartes)

  • Oliver Peters

    (Charité-Universitätsmedizin Berlin
    German Center for Neurodegenerative Diseases (DZNE))

  • Olivia Anna Skrobot

    (Southmead Hospital)

  • Olivier Quenez

    (FHU G4 Génomique)

  • Ondrej Lerch

    (Charles University
    St. Anne’s University Hospital Brno)

  • Paola Bossù

    (IRCCS Santa Lucia Foundation)

  • Paolo Caffarra

    (University of Parma)

  • Paolo Dionigi Rossi

    (IRCCS Ospedale Maggiore Policlinico)

  • Paraskevi Sakka

    (Athens Association of Alzheimer’s disease and Related Disorders)

  • Patrizia Mecocci

    (University of Perugia)

  • Per Hoffmann

    (School of Medicine & University Hospital Bonn
    University Hospital Basel)

  • Peter A. Holmans

    (Cardiff University)

  • Peter Fischer

    (Social Medicine Center East- Donauspital)

  • Peter Riederer

    (University Hospital of Würzburg)

  • Qiong Yang

    (Boston University School of Public Health)

  • Rachel Marshall

    (Cardiff University)

  • Rajesh N. Kalaria

    (Newcastle University
    Campus for Ageing anf Vitality)

  • Richard Mayeux

    (Columbia University
    Columbia University
    Columbia University)

  • Rik Vandenberghe

    (University of Leuven
    University Hospitals Leuven)

  • Roberta Cecchetti

    (University of Perugia)

  • Roberta Ghidoni

    (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli)

  • Ruth Frikke-Schmidt

    (Rigshospitalet
    University of Copenhagen)

  • Sandro Sorbi

    (Drug Research and Child Health University of Florence
    IRCCS Fondazione Don Carlo Gnocchi)

  • Sara Hägg

    (Karolinska Institutet)

  • Sebastiaan Engelborghs

    (Vrije Universiteit Brussel (VUB)
    University of Antwerp
    University of Antwerp
    VUB University Hospital Brussels (UZ Brussel))

  • Seppo Helisalmi

    (University of Eastern Finland)

  • Sigrid Botne Sando

    (University Hospital of Trondheim
    Norwegian University of Science and Technology)

  • Silke Kern

    (University of Gothenburg)

  • Silvana Archetti

    (Brescia Hospital)

  • Silvia Boschi

    (University of Torino)

  • Silvia Fostinelli

    (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli)

  • Silvia Gil

    (Universitat Internacional de Catalunya)

  • Silvia Mendoza

    (Andalusian Institute for Neuroscience)

  • Simon Mead

    (Institute of Prion Diseases)

  • Simona Ciccone

    (IRCCS Ospedale Maggiore Policlinico)

  • Srdjan Djurovic

    (Oslo University Hospital
    University of Bergen)

  • Stefanie Heilmann-Heimbach

    (School of Medicine & University Hospital Bonn)

  • Steffi Riedel-Heller

    (University of Leipzig)

  • Teemu Kuulasmaa

    (University of Eastern Finland)

  • Teodoro del Ser

    (Department of Neurology/CIEN Foundation/Queen Sofia Foundation Alzheimer Center)

  • Thibaud Lebouvier

    (Univ Lille
    CHU CNR-MAJ)

  • Thomas Polak

    (University Hospital)

  • Tiia Ngandu

    (Karolinska Institutet
    Finnish Institute for Health and Welfare)

  • Timo Grimmer

    (Technical University of Munich)

  • Valentina Bessi

    (Drug Research and Child Health University of Florence
    Azienda Ospedaliero-Universitaria Careggi Largo Brambilla)

  • Valentina Escott-Price

    (Cardiff University
    Cardiff University)

  • Vilmantas Giedraitis

    (Department of Public Health and Caring Sciences/Geriatrics)

  • Vincent Deramecourt

    (Univ Lille
    CHU CNR-MAJ)

  • Wolfgang Maier

    (University Clinic Bonn
    German Center for Neurodegenerative Diseases (DZNE))

  • Xueqiu Jian

    (Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases)

  • Yolande A. L. Pijnenburg

    (Vrije Universiteit Amsterdam, Amsterdam UMC)

  • Patrick Gavin Kehoe

    (Southmead Hospital)

  • Guillermo Garcia-Ribas

    (Hospital Universitario Ramon y Cajal, IRYCIS)

  • Pascual Sánchez-Juan

    (National Institute of Health Carlos III
    Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL))

  • Pau Pastor

    (Fundació Docència i Recerca MútuaTerrassa, Terrassa
    Hospital Universitari Mutua de Terrassa, Terrassa)

  • Jordi Pérez-Tur

    (National Institute of Health Carlos III
    Institut de Biomedicina de València-CSIC
    Instituto de Investigación Sanitaria La Fe)

  • Gerard Piñol-Ripoll

    (Hospital Universitari Santa Maria de Lleida
    Institut de Recerca Biomedica de Lleida (IRBLLeida))

  • Adolfo Lopez de Munain

    (National Institute of Health Carlos III
    Hospital Universitario Donostia
    Instituto Biodonostia
    University of the Basque Country)

  • Jose María García-Alberca

    (National Institute of Health Carlos III
    Andalusian Institute for Neuroscience)

  • María J. Bullido

    (National Institute of Health Carlos III
    Universidad Autónoma de Madrid
    Centro de Biología Molecular Severo Ochoa (UAM-CSIC)
    Instituto de Investigacion Sanitaria ‘Hospital la Paz’ (IdIPaz))

  • Victoria Álvarez

    (Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
    Hospital Universitario Central de Asturias)

  • Alberto Lleó

    (National Institute of Health Carlos III
    Universitat Autònoma de Barcelona)

  • Luis M. Real

    (Hospital Universitario de Valme
    Universidad de Málaga)

  • Pablo Mir

    (National Institute of Health Carlos III
    Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla)

  • Miguel Medina

    (National Institute of Health Carlos III
    CIEN Foundation/Queen Sofia Foundation Alzheimer Center)

  • Philip Scheltens

    (Vrije Universiteit Amsterdam, Amsterdam UMC)

  • Henne Holstege

    (Vrije Universiteit Amsterdam, Amsterdam UMC
    Vrije Universiteit Amsterdam, Amsterdam UMC)

  • Marta Marquié

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • María Eugenia Sáez

    (CAEBI, Centro Andaluz de Estudios Bioinformáticos)

  • Ángel Carracedo

    (Universidade de Santiago de Compostela
    Fundación Pública Galega de Medicina Xenómica-CIBERER-IDIS)

  • Philippe Amouyel

    (U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases)

  • Gerard D. Schellenberg

    (University of Pennsylvania Perelman School of Medicine)

  • Julie Williams

    (Cardiff University
    Cardiff University)

  • Sudha Seshadri

    (Boston University School of Medicine
    Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases
    Framingham Heart Study)

  • Cornelia M. van Duijn

    (Erasmus Medical Center
    University of Oxford)

  • Karen A. Mather

    (University of New South Wales
    Neuroscience Research Australia)

  • Raquel Sánchez-Valle

    (University of Barcelona)

  • Manuel Serrano-Ríos

    (Hospital Clínico San Carlos (IdISSC)
    Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM))

  • Adelina Orellana

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Lluís Tárraga

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Kaj Blennow

    (Sahlgrenska University Hospital
    Sahlgrenska Academy at the University of Gothenburg)

  • Martijn Huisman

    (Amsterdam Public Health Research Institute
    VU University)

  • Ole A. Andreassen

    (University of Oslo
    Oslo University Hospital)

  • Danielle Posthuma

    (VU University)

  • Jordi Clarimón

    (National Institute of Health Carlos III
    Universitat Autònoma de Barcelona)

  • Mercè Boada

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

  • Wiesje M. van der Flier

    (Vrije Universiteit Amsterdam, Amsterdam UMC)

  • Alfredo Ramirez

    (Medical Faculty
    University Clinic Bonn
    German Center for Neurodegenerative Diseases (DZNE)
    Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases)

  • Jean-Charles Lambert

    (U1167-Labex DISTALZ-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases)

  • Sven J. van der Lee

    (Vrije Universiteit Amsterdam, Amsterdam UMC
    Vrije Universiteit Amsterdam, Amsterdam UMC)

  • Agustín Ruiz

    (Universitat Internacional de Catalunya
    National Institute of Health Carlos III)

Abstract

Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease.

Suggested Citation

  • Itziar Rojas & Sonia Moreno-Grau & Niccolo Tesi & Benjamin Grenier-Boley & Victor Andrade & Iris E. Jansen & Nancy L. Pedersen & Najada Stringa & Anna Zettergren & Isabel Hernández & Laura Montrreal &, 2021. "Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22491-8
    DOI: 10.1038/s41467-021-22491-8
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    Cited by:

    1. James M. Roe & Didac Vidal-Piñeiro & Øystein Sørensen & Håkon Grydeland & Esten H. Leonardsen & Olena Iakunchykova & Mengyu Pan & Athanasia Mowinckel & Marie Strømstad & Laura Nawijn & Yuri Milaneschi, 2024. "Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Gemma Shireby & Emma L. Dempster & Stefania Policicchio & Rebecca G. Smith & Ehsan Pishva & Barry Chioza & Jonathan P. Davies & Joe Burrage & Katie Lunnon & Dorothea Seiler Vellame & Seth Love & Alan , 2022. "DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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