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Comprehensive omic characterization of breast cancer in Mexican-Hispanic women

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  • Sandra L. Romero-Cordoba

    (Universidad Nacional Autónoma de México
    National Institute of Genomic Medicine
    Biochemistry Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán)

  • Ivan Salido-Guadarrama

    (Laboratorio de Biología Computacional, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas)

  • Rosa Rebollar-Vega

    (National Institute of Genomic Medicine
    Genomics Laboratory, Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México-Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
    Universidad Nacional Autónoma de México (UNAM))

  • Veronica Bautista-Piña

    (Instituto de Enfermedades de la Mama FUCAM)

  • Carlos Dominguez-Reyes

    (Instituto de Enfermedades de la Mama FUCAM)

  • Alberto Tenorio-Torres

    (Instituto de Enfermedades de la Mama FUCAM)

  • Felipe Villegas-Carlos

    (Instituto de Enfermedades de la Mama FUCAM)

  • Juan C. Fernández-López

    (National Institute of Genomic Medicine)

  • Laura Uribe-Figueroa

    (National Institute of Genomic Medicine)

  • Luis Alfaro-Ruiz

    (National Institute of Genomic Medicine)

  • Alfredo Hidalgo-Miranda

    (National Institute of Genomic Medicine)

Abstract

Breast cancer is a heterogeneous pathology, but the genomic basis of its variability remains poorly understood in populations other than Caucasians. Here, through DNA and RNA portraits we explored the molecular features of breast cancers in a set of Hispanic-Mexican (HM) women and compared them to public multi-ancestry datasets. HM patients present an earlier onset of the disease, particularly in aggressive clinical subtypes, compared to non-Hispanic women. The age-related COSMIC signature 1 was more frequent in HM women than in those from other ancestries. We found the AKT1E17K hotspot mutation in 8% of the HM women and identify the AKT1/PIK3CA axis as a potentially druggable target. Also, HM luminal breast tumors present an enhanced immunogenic phenotype compared to Asiatic and Caucasian tumors. This study is an initial effort to include patients from Hispanic populations in the research of breast cancer etiology and biology to further understand breast cancer disparities.

Suggested Citation

  • Sandra L. Romero-Cordoba & Ivan Salido-Guadarrama & Rosa Rebollar-Vega & Veronica Bautista-Piña & Carlos Dominguez-Reyes & Alberto Tenorio-Torres & Felipe Villegas-Carlos & Juan C. Fernández-López & L, 2021. "Comprehensive omic characterization of breast cancer in Mexican-Hispanic women," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22478-5
    DOI: 10.1038/s41467-021-22478-5
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