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The E3 ligase MREL57 modulates microtubule stability and stomatal closure in response to ABA

Author

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  • Liru Dou

    (China Agricultural University)

  • Kaikai He

    (China Agricultural University)

  • Jialin Peng

    (China Agricultural University)

  • Xiangfeng Wang

    (China Agricultural University)

  • Tonglin Mao

    (China Agricultural University)

Abstract

Regulation of stomatal movement is critical for plant adaptation to environmental stresses. The microtubule cytoskeleton undergoes disassembly, which is critical for stomatal closure in response to abscisic acid (ABA). However, the mechanism underlying this regulation largely remains unclear. Here we show that a ubiquitin-26S proteasome (UPS)-dependent pathway mediates microtubule disassembly and is required for ABA-induced stomatal closure. Moreover, we identify and characterize the ubiquitin E3 ligase MREL57 (MICROTUBULE-RELATED E3 LIGASE57) and the microtubule-stabilizing protein WDL7 (WAVE-DAMPENED2-LIKE7) in Arabidopsis and show that the MREL57-WDL7 module regulates microtubule disassembly to mediate stomatal closure in response to drought stress and ABA treatment. MREL57 interacts with, ubiquitinates and degrades WDL7, and this effect is clearly enhanced by ABA. ABA-induced stomatal closure and microtubule disassembly are significantly suppressed in mrel57 mutants, and these phenotypes can be restored when WDL7 expression is decreased. Our results unravel UPS-dependent mechanisms and the role of an MREL57-WDL7 module in microtubule disassembly and stomatal closure in response to drought stress and ABA.

Suggested Citation

  • Liru Dou & Kaikai He & Jialin Peng & Xiangfeng Wang & Tonglin Mao, 2021. "The E3 ligase MREL57 modulates microtubule stability and stomatal closure in response to ABA," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22455-y
    DOI: 10.1038/s41467-021-22455-y
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    Cited by:

    1. Hua Zhong & Shuwei Wang & Yaohui Huang & Xiankui Cui & Xuening Ding & Lei Zhu & Ming Yuan & Ying Fu, 2024. "Endomembrane trafficking driven by microtubule growth regulates stomatal movement in Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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