Author
Listed:
- Jake W. Rhodes
(The Westmead Institute for Medical Research
The University of Sydney)
- Rachel A. Botting
(The Westmead Institute for Medical Research
The University of Sydney
The University of Newcastle)
- Kirstie M. Bertram
(The Westmead Institute for Medical Research
The University of Sydney)
- Erica E. Vine
(The Westmead Institute for Medical Research
The University of Sydney)
- Hafsa Rana
(The Westmead Institute for Medical Research
The University of Sydney)
- Heeva Baharlou
(The Westmead Institute for Medical Research
The University of Sydney)
- Peter Vegh
(The University of Newcastle)
- Thomas R. O’Neil
(The Westmead Institute for Medical Research
The University of Sydney)
- Anneliese S. Ashhurst
(The University of Sydney)
- James Fletcher
(The University of Newcastle)
- Grant P. Parnell
(The Westmead Institute for Medical Research
The University of Sydney)
- J. Dinny Graham
(The Westmead Institute for Medical Research
The University of Sydney)
- Najla Nasr
(The Westmead Institute for Medical Research
The University of Sydney)
- Jake J. K. Lim
(Dr Jake Lim PLC)
- Laith Barnouti
(Australia Plastic Surgery)
- Peter Haertsch
(Burns Unit, Concord Repatriation General Hospital)
- Martijn P. Gosselink
(The Westmead Institute for Medical Research
Westmead Hospital)
- Angelina Di Re
(The Westmead Institute for Medical Research
Westmead Hospital)
- Faizur Reza
(The Westmead Institute for Medical Research
Westmead Hospital)
- Grahame Ctercteko
(The Westmead Institute for Medical Research
Westmead Hospital)
- Gregory J. Jenkins
(Westmead Hospital)
- Andrew J. Brooks
(Westmead Hospital)
- Ellis Patrick
(The Westmead Institute for Medical Research
The University of Sydney)
- Scott N. Byrne
(The Westmead Institute for Medical Research
The University of Sydney)
- Eric Hunter
(Emory Vaccine Centre)
- Muzlifah A. Haniffa
(The University of Newcastle
Wellcome Sanger Institute
Newcastle Hospitals NHS Foundation Trust)
- Anthony L. Cunningham
(The Westmead Institute for Medical Research
The University of Sydney)
- Andrew N. Harman
(The Westmead Institute for Medical Research
The University of Sydney)
Abstract
Tissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. As such they deliver HIV to its primary target cells; CD4 T cells. Most MNP HIV transmission studies have focused on epithelial MNPs. However, as mucosal trauma and inflammation are now known to be strongly associated with HIV transmission, here we examine the role of sub-epithelial MNPs which are present in a diverse array of subsets. We show that HIV can penetrate the epithelial surface to interact with sub-epithelial resident MNPs in anogenital explants and define the full array of subsets that are present in the human anogenital and colorectal tissues that HIV may encounter during sexual transmission. In doing so we identify two subsets that preferentially take up HIV, become infected and transmit the virus to CD4 T cells; CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 (cDC2).
Suggested Citation
Jake W. Rhodes & Rachel A. Botting & Kirstie M. Bertram & Erica E. Vine & Hafsa Rana & Heeva Baharlou & Peter Vegh & Thomas R. O’Neil & Anneliese S. Ashhurst & James Fletcher & Grant P. Parnell & J. D, 2021.
"Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells,"
Nature Communications, Nature, vol. 12(1), pages 1-15, December.
Handle:
RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22375-x
DOI: 10.1038/s41467-021-22375-x
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