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The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones

Author

Listed:
  • Netta Shemesh

    (Ben-Gurion University of the Negev
    Ben-Gurion University of the Negev)

  • Juman Jubran

    (Ben-Gurion University of the Negev)

  • Shiran Dror

    (Ben-Gurion University of the Negev)

  • Eyal Simonovsky

    (Ben-Gurion University of the Negev)

  • Omer Basha

    (Ben-Gurion University of the Negev)

  • Chanan Argov

    (Ben-Gurion University of the Negev)

  • Idan Hekselman

    (Ben-Gurion University of the Negev)

  • Mehtap Abu-Qarn

    (Ben-Gurion University of the Negev)

  • Ekaterina Vinogradov

    (Ben-Gurion University of the Negev)

  • Omry Mauer

    (Ben-Gurion University of the Negev)

  • Tatiana Tiago

    (University of Modena and Reggio Emilia)

  • Serena Carra

    (University of Modena and Reggio Emilia)

  • Anat Ben-Zvi

    (Ben-Gurion University of the Negev)

  • Esti Yeger-Lotem

    (Ben-Gurion University of the Negev)

Abstract

The sensitivity of the protein-folding environment to chaperone disruption can be highly tissue-specific. Yet, the organization of the chaperone system across physiological human tissues has received little attention. Through computational analyses of large-scale tissue transcriptomes, we unveil that the chaperone system is composed of core elements that are uniformly expressed across tissues, and variable elements that are differentially expressed to fit with tissue-specific requirements. We demonstrate via a proteomic analysis that the muscle-specific signature is functional and conserved. Core chaperones are significantly more abundant across tissues and more important for cell survival than variable chaperones. Together with variable chaperones, they form tissue-specific functional networks. Analysis of human organ development and aging brain transcriptomes reveals that these functional networks are established in development and decline with age. In this work, we expand the known functional organization of de novo versus stress-inducible eukaryotic chaperones into a layered core-variable architecture in multi-cellular organisms.

Suggested Citation

  • Netta Shemesh & Juman Jubran & Shiran Dror & Eyal Simonovsky & Omer Basha & Chanan Argov & Idan Hekselman & Mehtap Abu-Qarn & Ekaterina Vinogradov & Omry Mauer & Tatiana Tiago & Serena Carra & Anat Be, 2021. "The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22369-9
    DOI: 10.1038/s41467-021-22369-9
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    Cited by:

    1. Antonia Vogel & Renato Arnese & Ricardo M. Gudino Carrillo & Daria Sehr & Luiza Deszcz & Andrzej Bylicki & Anton Meinhart & Tim Clausen, 2024. "UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Rebecca San Gil & Dana Pascovici & Juliana Venturato & Heledd Brown-Wright & Prachi Mehta & Lidia Madrid San Martin & Jemma Wu & Wei Luan & Yi Kit Chui & Adekunle T. Bademosi & Shilpa Swaminathan & Se, 2024. "A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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