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Association of sleep duration in middle and old age with incidence of dementia

Author

Listed:
  • Séverine Sabia

    (Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases
    University College London)

  • Aurore Fayosse

    (Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases)

  • Julien Dumurgier

    (Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases
    Université de Paris, Inserm U1144, Cognitive Neurology Center, GHU APHP Nord Lariboisière – Fernand Widal Hospital)

  • Vincent T. Hees

    (Accelting, Andorrastraat 13)

  • Claire Paquet

    (Université de Paris, Inserm U1144, Cognitive Neurology Center, GHU APHP Nord Lariboisière – Fernand Widal Hospital)

  • Andrew Sommerlad

    (University College London
    Camden and Islington NHS Foundation Trust)

  • Mika Kivimäki

    (University College London
    Clinicum, University of Helsinki)

  • Aline Dugravot

    (Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases)

  • Archana Singh-Manoux

    (Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases
    University College London)

Abstract

Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7 h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1.22 (95% confidence interval 1.01–1.48), 1.37 (1.10–1.72), and 1.24 (0.98–1.57), respectively). Persistent short sleep duration at age 50, 60, and 70 compared to persistent normal sleep duration was also associated with a 30% increased dementia risk independently of sociodemographic, behavioural, cardiometabolic, and mental health factors. These findings suggest that short sleep duration in midlife is associated with an increased risk of late-onset dementia.

Suggested Citation

  • Séverine Sabia & Aurore Fayosse & Julien Dumurgier & Vincent T. Hees & Claire Paquet & Andrew Sommerlad & Mika Kivimäki & Aline Dugravot & Archana Singh-Manoux, 2021. "Association of sleep duration in middle and old age with incidence of dementia," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22354-2
    DOI: 10.1038/s41467-021-22354-2
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    Cited by:

    1. Blanchflower, David G. & Bryson, Alex, 2021. "Unemployment and sleep: evidence from the United States and Europe," Economics & Human Biology, Elsevier, vol. 43(C).
    2. Yann Vanrobaeys & Zeru J. Peterson & Emily. N. Walsh & Snehajyoti Chatterjee & Li-Chun Lin & Lisa C. Lyons & Thomas Nickl-Jockschat & Ted Abel, 2023. "Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Wei Li & Ning Sun & Anthony Kondracki & Wenjie Sun, 2021. "Sex, Sleep Duration, and the Association of Cognition: Findings from the China Health and Retirement Longitudinal Study," IJERPH, MDPI, vol. 18(19), pages 1-11, September.

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