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Adult-born neurons immature during learning are necessary for remote memory reconsolidation in rats

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  • Marie Lods

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Emilie Pacary

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Wilfrid Mazier

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Fanny Farrugia

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Pierre Mortessagne

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Nuria Masachs

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Vanessa Charrier

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Federico Massa

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Daniela Cota

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Guillaume Ferreira

    (INRA, Bordeaux INP, Nutrition and Integrative Neurobiology, UMR 1286)

  • Djoher Nora Abrous

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Sophie Tronel

    (University of Bordeaux, INSERM, Neurocentre Magendie, U1215)

Abstract

Memory reconsolidation, the process by which memories are again stabilized after being reactivated, has strengthened the idea that memory stabilization is a highly plastic process. To date, the molecular and cellular bases of reconsolidation have been extensively investigated particularly within the hippocampus. However, the role of adult neurogenesis in memory reconsolidation is unclear. Here, we combined functional imaging, retroviral and chemogenetic approaches in rats to tag and manipulate different populations of rat adult-born neurons. We find that both mature and immature adult-born neurons are activated by remote memory retrieval. However, only specific silencing of the adult-born neurons immature during learning impairs remote memory retrieval-induced reconsolidation. Hence, our findings show that adult-born neurons immature during learning are required for the maintenance and update of remote memory reconsolidation.

Suggested Citation

  • Marie Lods & Emilie Pacary & Wilfrid Mazier & Fanny Farrugia & Pierre Mortessagne & Nuria Masachs & Vanessa Charrier & Federico Massa & Daniela Cota & Guillaume Ferreira & Djoher Nora Abrous & Sophie , 2021. "Adult-born neurons immature during learning are necessary for remote memory reconsolidation in rats," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22069-4
    DOI: 10.1038/s41467-021-22069-4
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