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All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis

Author

Listed:
  • Kyunghun Kim

    (Purdue University)

  • Ho Joong Kim

    (Purdue University)

  • Haozhe Zhang

    (University of Virginia)

  • Woohyun Park

    (Purdue University)

  • Dawn Meyer

    (Indiana University)

  • Min Ku Kim

    (Purdue University)

  • Bongjoong Kim

    (Purdue University)

  • Heun Park

    (Purdue University)

  • Baoxing Xu

    (University of Virginia)

  • Pete Kollbaum

    (Indiana University)

  • Bryan W. Boudouris

    (Purdue University
    Purdue University)

  • Chi Hwan Lee

    (Purdue University
    Purdue University
    Purdue University)

Abstract

Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typically requires the use of topical anesthesia and a speculum for pain management and safety. Here we report a design of an all-printed stretchable corneal sensor built on commercially-available disposable soft contact lenses that can intimately and non-invasively interface with the corneal surface of human eyes. The corneal sensor is integrated with soft contact lenses via an electrochemical anchoring mechanism in a seamless manner that ensures its mechanical and chemical reliability. Thus, the resulting device enables the high-fidelity recording of full-field electroretinogram signals in human eyes without the need of topical anesthesia or a speculum. The device, superior to clinical standards in terms of signal quality and comfortability, is expected to address unmet clinical needs in the field of ocular electrodiagnosis.

Suggested Citation

  • Kyunghun Kim & Ho Joong Kim & Haozhe Zhang & Woohyun Park & Dawn Meyer & Min Ku Kim & Bongjoong Kim & Heun Park & Baoxing Xu & Pete Kollbaum & Bryan W. Boudouris & Chi Hwan Lee, 2021. "All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21916-8
    DOI: 10.1038/s41467-021-21916-8
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    Cited by:

    1. Hengtian Zhu & Huan Yang & Siqi Xu & Yuanyuan Ma & Shugeng Zhu & Zhengyi Mao & Weiwei Chen & Zizhong Hu & Rongrong Pan & Yurui Xu & Yifeng Xiong & Ye Chen & Yanqing Lu & Xinghai Ning & Dechen Jiang & , 2024. "Frequency-encoded eye tracking smart contact lens for human–machine interaction," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Jinyuan Zhang & Kyunghun Kim & Ho Joong Kim & Dawn Meyer & Woohyun Park & Seul Ah Lee & Yumin Dai & Bongjoong Kim & Haesoo Moon & Jay V. Shah & Keely E. Harris & Brett Collar & Kangying Liu & Pedro Ir, 2022. "Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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